Molecular structure of Gabapentin-lactam, CAS Number: 64744-50-9
Gabapentin-lactam (CAS 64744-50-9)
Alternate Names:
β, β-pentamethylen-gamma-butyrolactam
Application:
Gabapentin-lactam is a potassium channel modulator and potential neuroprotector
CAS Number:
64744-50-9
Purity:
≥98%
Molecular Weight:
153.2
Molecular Formula:
C9H15NO
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Gabapentin-lactam, a cell permeable compound, has been reported to reduce oxygen glucose deprivation-induced [3H]glutamate release in rat ischemia hippocampal slices. Glutamate has been an excitotoxin and its inhibition can decrease the number of surviving ganglion cells in vitro. In mechanistic studies it has been demonstrated that the neuroprotective characteristics of Gabapentin-lactam take effect via opening of ATP-sensitive potassium channels.
Gabapentin-lactam (CAS 64744-50-9) References
- Gabapentin-lactam, a close analogue of the anticonvulsant gabapentin, exerts convulsant activity in amygdala kindled rats. | Potschka, H., et al. 2000. Naunyn Schmiedebergs Arch Pharmacol. 361: 200-5. PMID: 10685877
- Gabapentin-lactam (8-aza-spiro[5,4]decan-9-on; GBP-L) inhibits oxygen glucose deprivation-induced [3H]glutmate release and is a neuroprotective agent in amodel of acute retinal ischemia. | Jehle, T., et al. 2000. Naunyn Schmiedebergs Arch Pharmacol. 362: 74-81. PMID: 10935536
- The neuroprotective properties of gabapentin-lactam. | Lagrèze, WA., et al. 2001. Graefes Arch Clin Exp Ophthalmol. 239: 845-9. PMID: 11789865
- Retinal ganglion cell survival is enhanced by gabapentin-lactam in vitro: evidence for involvement of mitochondrial KATP channels. | Pielen, A., et al. 2004. Graefes Arch Clin Exp Ophthalmol. 242: 240-4. PMID: 14770318
- Gabapentin-lactam, but not gabapentin, reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington's disease. | Zucker, B., et al. 2004. Naunyn Schmiedebergs Arch Pharmacol. 370: 131-9. PMID: 15322735
- Gabapentin-lactam induces dendritic filopodia and motility in cultured hippocampal neurons. | Henle, F., et al. 2006. J Pharmacol Exp Ther. 319: 181-91. PMID: 16844845
- Kinetic model for solid-state degradation of gabapentin. | Zong, Z., et al. 2012. J Pharm Sci. 101: 2123-33. PMID: 22419014
- Effect of gabapentin-lactam and gamma-aminobutyric acid/lactam analogs on proliferation and phenotype of ovine mesenchymal stem cells. | Sauerbier, S., et al. 2013. Int J Oral Maxillofac Implants. 28: e230-8. PMID: 24066334
- The effect of gabapentin-lactam hydroxamic acid derivatives on ovine osteoblast proliferation and phenotype: perspectives for tissue engineering application. | Duttenhoefer, F., et al. 2014. Int J Oral Maxillofac Implants. 29: e73-80. PMID: 24451891
- Can mesenchymal stem cells and novel gabapentin-lactam enhance maxillary bone formation? | Oshima, T., et al. 2014. J Oral Maxillofac Surg. 72: 485-95. PMID: 24528562
- Theoretical mechanistic insight into the gabapentin lactamization by an intramolecular attack: Degradation model and stabilization factors. | Hadidi, S., et al. 2020. J Pharm Biomed Anal. 178: 112900. PMID: 31629973
- Development of an analytical method to quantify pharmaceuticals in fish tissues by liquid chromatography-tandem mass spectrometry detection and application to environmental samples. | Boulard, L., et al. 2020. J Chromatogr A. 1633: 461612. PMID: 33130421
- Simultaneous attenuation of trace organics and change in organic matter composition in the hyporheic zone of urban streams. | Mueller, BM., et al. 2021. Sci Rep. 11: 4179. PMID: 33603043
- Toxicity of gabapentin-lactam on the early developmental stage of zebrafish (Danio rerio). | He, Y., et al. 2021. Environ Pollut. 287: 117649. PMID: 34182397
- Fate of trace organic compounds in the hyporheic zone: Influence of microbial metabolism. | Höhne, A., et al. 2022. Water Res. 224: 119056. PMID: 36126632
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Gabapentin-lactam, 50 mg | sc-201003 | 50 mg | $70.00 | |||
Gabapentin-lactam, 250 mg | sc-201003A | 250 mg | $205.00 |