Molecular structure of GABA, CAS Number: 56-12-2
GABA (CAS 56-12-2)
See product citations (2)
Alternate Names:
4-Aminobutyric acid
Application:
GABA is an inhibitory neurotransmitter in the CNS
CAS Number:
56-12-2
Purity:
≥98%
Molecular Weight:
103.12
Molecular Formula:
C4H9NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
GABA is the major inhibitory neurotransmitter in the mammalian central nervous system. GABA is an activator of GABA Receptor. GABA is a neurotransmitter present in the central nervous system (CNS) of mammals. Functioning as an inhibitory neurotransmitter, GABA exerts a calming influence on the brain and nervous system. It participates in various physiological processes, encompassing mood regulation, motor control, and cognitive functions. Acting through two types of receptors, namely gamma-Aminobutyric acid-A and gamma-Aminobutyric acid-B, GABA′s activity is modulated by diverse drugs and hormones.
GABA (CAS 56-12-2) References
- Differential effects on motorcortical inhibition induced by blockade of GABA uptake in humans. | Werhahn, KJ., et al. 1999. J Physiol. 517 (Pt 2): 591-7. PMID: 10332104
- GABA-level increasing and anticonvulsant effects of three different GABA uptake inhibitors. | Dalby, NO. 2000. Neuropharmacology. 39: 2399-407. PMID: 10974324
- A new role for GABA: inhibition of tumor cell migration. | Ortega, A. 2003. Trends Pharmacol Sci. 24: 151-4. PMID: 12706998
- The gamma-aminobutyric acid (GABA) uptake inhibitor, tiagabine, increases extracellular brain levels of GABA in awake rats. | Fink-Jensen, A., et al. 1992. Eur J Pharmacol. 220: 197-201. PMID: 1425991
- Effects of the GABA uptake inhibitor tiagabine on inhibitory synaptic potentials in rat hippocampal slice cultures. | Thompson, SM. and Gähwiler, BH. 1992. J Neurophysiol. 67: 1698-701. PMID: 1629773
- GABA: a dominant neurotransmitter in the hypothalamus. | Decavel, C. and Van den Pol, AN. 1990. J Comp Neurol. 302: 1019-37. PMID: 2081813
- Advantages of an antagonist: bicuculline and other GABA antagonists. | Johnston, GA. 2013. Br J Pharmacol. 169: 328-36. PMID: 23425285
- Oxytocin-mediated GABA inhibition during delivery attenuates autism pathogenesis in rodent offspring. | Tyzio, R., et al. 2014. Science. 343: 675-9. PMID: 24503856
- Comparing GABA-dependent physiological measures of inhibition with proton magnetic resonance spectroscopy measurement of GABA using ultra-high-field MRI. | Dyke, K., et al. 2017. Neuroimage. 152: 360-370. PMID: 28284797
- Modification of orientation sensitivity of cat visual cortex neurons by removal of GABA-mediated inhibition. | Tsumoto, T., et al. 1979. Exp Brain Res. 34: 351-63. PMID: 421752
- A review of the preclinical pharmacology of tiagabine: a potent and selective anticonvulsant GABA uptake inhibitor. | Suzdak, PD. and Jansen, JA. 1995. Epilepsia. 36: 612-26. PMID: 7555976
- Effects of the GABA-uptake inhibitor tiagabine on electroencephalogram, spike-wave discharges and behaviour of rats. | Coenen, AM., et al. 1995. Epilepsy Res. 21: 89-94. PMID: 7588592
- GABAc receptors: relatively simple transmitter -gated ion channels? | Johnston, GA. 1996. Trends Pharmacol Sci. 17: 319-23. PMID: 8885697
- GABA and its receptors in the spinal cord. | Malcangio, M. and Bowery, NG. 1996. Trends Pharmacol Sci. 17: 457-62. PMID: 9014500
Inhibitor of:
B230216G23Rik, GAP-43, GnRH I, Olfr853, Olfr854, Olr242, and P5CRL.Activator of:
ABAT, ADNP, AIDA-1, Amylin, B230216G23Rik, Bhlhb9, Brp16, C8orf57, Cerebellin 2, Chromozym X, copine 3, cortexin 1, DNPEP, DOC2A, FRMD4A, FSHα, Gγ 2, GABA Receptor, GABA T-3, GABAA R α 2, GH-2, GHRH, GlyR α4, GRIF-1, HIAT1, HLA-3, HNK-1ST, ICSBP, KCTD12, KMCP1, KV1.2, LOC257407, MafA, MUP20, Na+ CP type IIIα, Neurexophilin-4, NGFR p75, Olah, Olfr47, Olfr814, Olfr815, Olfr816, Olfr818, Olfr820, Olfr821, Olfr822, Olfr823, Olr1104, OR4F6, OR5F1, OR7G2, OTTMUSG00000007521, OTTMUSG00000007855, OTTMUSG00000008081, OTTMUSG00000008385, OTTMUSG00000008394, OTTMUSG00000011273, OTTMUSG00000016321, OX2, PCDHB10_Pcdhb10, PCP4L1, PSD2, Relaxin 3, RFPL4, RFRP-1, SAPAP4, SCGN, SGS2, SLM-1, SYP, Tachykinin 4, TAUT, Teneurin-3, TMEM16B, TRH-R2, V1RB4, V1RD13, V1RD6, V1RH2, V1RH21, V1RH7, VAChT, Vmn1r184, Vmn1r92, Vmn2r100, Vmn2r102, Vmn2r105, Vmn2r11, Vmn2r12, Vmn2r122, Vmn2r14, and VSTM3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GABA, 10 g | sc-203053 | 10 g | $63.00 | |||
GABA, 25 g | sc-203053A | 25 g | $133.00 | |||
GABA, 5 kg | sc-203053B | 5 kg | $450.00 | |||
GABA, 10 kg | sc-203053C | 10 kg | $750.00 |