Molecular structure of Ga(III) Protoporphyrin IX Chloride, CAS Number: 210409-12-4
Ga(III) Protoporphyrin IX Chloride (CAS 210409-12-4)
Alternate Names:
Gallium(III) Protoporphyrin IX Chloride
Application:
Ga(III) Protoporphyrin IX Chloride is Ga(III) Protoporphyrin IX Chloride is a gallium protoporphyrin.
CAS Number:
210409-12-4
Molecular Weight:
665.82
Molecular Formula:
C34H32ClGaN4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Ga(III) Protoporphyrin IX Chloride, also known as GaPP, is a gallium protoporphyrin. It is a synthetic derivative of heme, a naturally occurring molecule found in hemoglobin and other hemoproteins. It is considered a competitive inhibitor of heme oxygenase-1 (HO-1), an enzyme responsible for the breakdown of heme. By inhibiting HO-1, Ga(III) Protoporphyrin IX Chloride can modulate the cellular levels of heme and its breakdown products, leading to various biological effects. For example, inhibition of HO-1 by Ga(III) Protoporphyrin IX Chloride can induce oxidative stress and promote apoptosis in cancer cells.
Ga(III) Protoporphyrin IX Chloride (CAS 210409-12-4) References
- Anticancer Gold(III) Porphyrins Target Mitochondrial Chaperone Hsp60. | Hu, D., et al. 2016. Angew Chem Int Ed Engl. 55: 1387-91. PMID: 26663758
- Heme interaction of the intrinsically disordered N-terminal peptide segment of human cystathionine-β-synthase. | Kumar, A., et al. 2018. Sci Rep. 8: 2474. PMID: 29410458
- Rapid Uptake and Photodynamic Inactivation of Staphylococci by Ga(III)-Protoporphyrin IX. | Morales-de-Echegaray, AV., et al. 2018. ACS Infect Dis. 4: 1564-1573. PMID: 30175917
- Iron/Heme Metabolism-Targeted Gallium(III) Nanoparticles Are Active against Extracellular and Intracellular Pseudomonas aeruginosa and Acinetobacter baumannii. | Choi, SR., et al. 2019. Antimicrob Agents Chemother. 63: PMID: 30782994
- Dual Inhibition of Klebsiella pneumoniae and Pseudomonas aeruginosa Iron Metabolism Using Gallium Porphyrin and Gallium Nitrate. | Choi, SR., et al. 2019. ACS Infect Dis. 5: 1559-1569. PMID: 31264851
- Contemporary approaches and future perspectives of antibacterial photodynamic therapy (aPDT) against methicillin-resistant Staphylococcus aureus (MRSA): A systematic review. | Dharmaratne, P., et al. 2020. Eur J Med Chem. 200: 112341. PMID: 32505848
- Gallium Porphyrin and Gallium Nitrate Synergistically Inhibit Mycobacterial Species by Targeting Different Aspects of Iron/Heme Metabolism. | Choi, SR., et al. 2020. ACS Infect Dis. 6: 2582-2591. PMID: 32845117
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| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ga(III) Protoporphyrin IX Chloride, 50 mg | sc-396856 | 50 mg | $418.00 |