G6PT Antibody (7B9): sc-293321

G6PT Antibody (7B9) is a mouse monoclonal IgG2a kappa light chain antibody that detects G6PT protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). anti-G6PT antibody (7B9) is available as a non-conjugated format. G6PT, also known as glucose-6-phosphate translocase, is a 429 amino acid multi-pass membrane protein located in the endoplasmic reticulum and belongs to the solute carrier family 37, member 4 (SLC37A4). G6PT functions to transport glucose-6-phosphate from the cytoplasm into the lumen of the endoplasmic reticulum, a process vital for maintaining cellular energy homeostasis. G6PT shows high expression in liver and kidney, where G6PT plays a significant role in glycogenolysis and gluconeogenesis, metabolic pathways essential for regulating blood glucose levels. G6PT is also involved in ATP-mediated calcium sequestration within the endoplasmic reticulum, highlighting G6PT′s importance in cellular signaling and metabolic regulation. Mutations in G6PT can lead to glycogen storage disease type 1B (GSD1B), a serious condition characterized by impaired glycogen metabolism, underscoring G6PT′s critical function in energy balance and metabolic health.

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G6PT Antibody (7B9) References:

1. Inactivation of the glucose 6-phosphate transporter causes glycogen storage disease type 1b.  |  Hiraiwa, H., et al. 1999. J Biol Chem. 274: 5532-6. PMID: 10026167
2. Mutations in the glucose-6-phosphate transporter (G6PT) gene in patients with glycogen storage diseases type 1b and 1c.  |  Galli, L., et al. 1999. FEBS Lett. 459: 255-8. PMID: 10518030
3. Transport and transporters in the endoplasmic reticulum.  |  Csala, M., et al. 2007. Biochim Biophys Acta. 1768: 1325-41. PMID: 17466261
4. The glucose-6-phosphate transporter is a phosphate-linked antiporter deficient in glycogen storage disease type Ib and Ic.  |  Chen, SY., et al. 2008. FASEB J. 22: 2206-13. PMID: 18337460
5. Functional analysis of mutations in the glucose-6-phosphate transporter that cause glycogen storage disease type Ib.  |  Chen, SY., et al. 2008. Mol Genet Metab. 95: 220-3. PMID: 18835800
6. Evidence for transcriptional regulation of the glucose-6-phosphate transporter by HIF-1alpha: Targeting G6PT with mumbaistatin analogs in hypoxic mesenchymal stromal cells.  |  Lord-Dufour, S., et al. 2009. Stem Cells. 27: 489-97. PMID: 19074414
7. Sequence of a putative glucose 6-phosphate translocase, mutated in glycogen storage disease type Ib.  |  Gerin, I., et al. 1997. FEBS Lett. 419: 235-8. PMID: 9428641
8. A gene on chromosome 11q23 coding for a putative glucose- 6-phosphate translocase is mutated in glycogen-storage disease types Ib and Ic.  |  Veiga-da-Cunha, M., et al. 1998. Am J Hum Genet. 63: 976-83. PMID: 9758626
9. Genomic structure of the human glucose 6-phosphate translocase gene and novel mutations in the gene of a Japanese patient with glycogen storage disease type Ib.  |  Ihara, K., et al. 1998. Hum Genet. 103: 493-6. PMID: 9856496

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-G6PT Antibody (7B9) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-G6PT Antibody (7B9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

G6PT Antibody (7B9) Specifications

Alternate Product Name: G6PT

Product Clone Name: 7B9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 28-76

Epitope Target: G6PT

Epitope Species: human

Product Reactivity/Detection: G6PT

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for G6PT Antibody (7B9): N/A