Fusidic acid sodium salt (CAS 751-94-0)
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Fusidic acid sodium salt, a triterpenoid compound, displays a capacity to inhibit lysis of isolated islet cells by activated microphages via suppression of nitiric oxide toxicity. Other studies have shown Furisdic acid to have immunomodulatory effects related to decrease in cytokine production in animal models of insuln dependent diabetes and septic shock. In vitro studies suggest that Furisdic acid acts against many pathogens including Staphylococcus aureus, gram-positive anaerobic bacteria, Neisseria spp., Bordetella pertussis, and Moraxella catarrhalis. In addition, this compound has been noted to inhibit the function of neutrophils and T-lymphocytes. The mechanism behind these inhibitions is known to be due to interference of protein synthesis via suppression of EF-G (elongation factor G) at the level of the ribosome. This product is offered in the sodium salt form which is found to be more water-soluble.
Fusidic acid sodium salt (CAS 751-94-0) References
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- Sodium fusidate ameliorates the course of diabetes induced in mice by multiple low doses of streptozotocin. | Nicoletti, F., et al. 2000. J Autoimmun. 15: 395-405. PMID: 11090238
- Sodium fusidate (fusidin) ameliorates the course of monophasic experimental allergic encephalomyelitis in the Lewis rat. | Di Marco, R., et al. 2001. Mult Scler. 7: 101-4. PMID: 11424629
- Curative effects of sodium fusidate on the development of dinitrobenzenesulfonic acid-induced colitis in rats. | Di Marco, R., et al. 2003. Clin Immunol. 109: 266-71. PMID: 14697740
- Dumb and dumber--the potential waste of a useful antistaphylococcal agent: emerging fusidic acid resistance in Staphylococcus aureus. | Howden, BP. and Grayson, ML. 2006. Clin Infect Dis. 42: 394-400. PMID: 16392088
- Novel sodium fusidate-loaded film-forming hydrogel with easy application and excellent wound healing. | Kim, DW., et al. 2015. Int J Pharm. 495: 67-74. PMID: 26325319
- An Investigation of Sodium Fusidate and Recombinant Cytochrome P450 Enzymes Inhibition In-Vitro. | Mishriky, J., et al. 2016. Drug Metab Lett. 10: 180-186. PMID: 27280598
- Microencapsulated sodium fusidate to impart antibacterial properties into cotton dressings for traumatic wounds. | Rajapakse, RDN., et al. 2022. J Wound Care. 31: 99-109. PMID: 35077219
- Preclinical development of sodium fusidate antibiotic cutaneous spray based on water-free lipid formulation system. | Holmbäck, J., et al. 2022. Eur J Pharm Sci. 176: 106250. PMID: 35779822
- Comparison of susceptibility of Neisseria meningitidis to sodium sulphadiazine and sodium fusidate in vitro. | Miles, RS. and Moyes, A. 1978. J Clin Pathol. 31: 355-8. PMID: 417095
- Micellar properties of sodium fusidate, a steroid antibiotic structurally resembling the bile salts. | Carey, MC. and Small, DM. 1971. J Lipid Res. 12: 604-13. PMID: 5098396
- Fusidic acid suppresses nitric oxide toxicity in pancreatic islet cells. | Burkart, V., et al. 1994. Biochem Pharmacol. 48: 1379-85. PMID: 7945436
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fusidic acid sodium salt, 50 mg | sc-202164 | 50 mg | $32.00 |