Molecular structure of Fursultiamine, CAS Number: 804-30-8
Fursultiamine (CAS 804-30-8)
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Alternate Names:
Alinamin F; TTFD
Application:
Fursultiamine is a disulfide derivative of thiamine
CAS Number:
804-30-8
Molecular Weight:
398.54
Molecular Formula:
C17H26N4O3S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Fursultiamine is a synthetic derivative of thiamine (vitamin B1) that is used in research to study vitamin B1 uptake and metabolism. Unlike thiamine, fursultiamine is lipid-soluble, which allows it to be used in studies aimed at understanding the kinetics of thiamine derivatives. Research involving fursultiamine often focuses on its conversion to thiamine in the body and the subsequent effects on thiamine-dependent enzymes. Researchers are interested in how fursultiamine influences thiamine pyrophosphate (TPP) levels within cells and its role in modulating enzyme activity in the thiamine-dependent processes of carbohydrate and amino acid metabolism. Additionally, fursultiamine is studied in the context of its effects on neurological functions, as thiamine deficiency is known to lead to neurological impairments.
Fursultiamine (CAS 804-30-8) References
- Fursultiamine, a vitamin B1 derivative, enhances chondroprotective effects of glucosamine hydrochloride and chondroitin sulfate in rabbit experimental osteoarthritis. | Kobayashi, T., et al. 2005. Inflamm Res. 54: 249-55. PMID: 15973508
- Powerful beneficial effects of benfotiamine on cognitive impairment and beta-amyloid deposition in amyloid precursor protein/presenilin-1 transgenic mice. | Pan, X., et al. 2010. Brain. 133: 1342-51. PMID: 20385653
- High-throughput screening of small molecules identifies hepcidin antagonists. | Fung, E., et al. 2013. Mol Pharmacol. 83: 681-90. PMID: 23292796
- Glial cell ceruloplasmin and hepcidin differentially regulate iron efflux from brain microvascular endothelial cells. | McCarthy, RC. and Kosman, DJ. 2014. PLoS One. 9: e89003. PMID: 24533165
- Toll-Like Receptor 4/MyD88-Mediated Signaling of Hepcidin Expression Causing Brain Iron Accumulation, Oxidative Injury, and Cognitive Impairment After Intracerebral Hemorrhage. | Xiong, XY., et al. 2016. Circulation. 134: 1025-1038. PMID: 27576776
- Identification of Guanosine 5'-diphosphate as Potential Iron Mobilizer: Preventing the Hepcidin-Ferroportin Interaction and Modulating the Interleukin-6/Stat-3 Pathway. | Angmo, S., et al. 2017. Sci Rep. 7: 40097. PMID: 28054602
- Detection and quantification of phenethylamines in sports dietary supplements by NMR approach. | Zhao, J., et al. 2018. J Pharm Biomed Anal. 151: 347-355. PMID: 29413984
- Liquid chromatography-quadrupole time of flight mass spectrometric method for targeted analysis of 111 nitrogen-based compounds in weight loss and ergogenic supplements. | Avula, B., et al. 2019. J Pharm Biomed Anal. 174: 305-323. PMID: 31195319
- Therapeutic Advances in Regulating the Hepcidin/Ferroportin Axis. | Hawula, ZJ., et al. 2019. Pharmaceuticals (Basel). 12: PMID: 31775259
- Production of a monoclonal antibody for the detection of vitamin B1 and its use in an indirect enzyme-linked immunosorbent assay and immunochromatographic strip. | Zeng, L., et al. 2020. J Mater Chem B. 8: 1935-1943. PMID: 32065194
- Dibenzoylthiamine Has Powerful Antioxidant and Anti-Inflammatory Properties in Cultured Cells and in Mouse Models of Stress and Neurodegeneration. | Sambon, M., et al. 2020. Biomedicines. 8: PMID: 32962139
- Fursultiamine Alleviates Choroidal Neovascularization by Suppressing Inflammation and Metabolic Reprogramming. | Do, JY., et al. 2020. Invest Ophthalmol Vis Sci. 61: 24. PMID: 33107903
- Effect of hepcidin antagonists on anemia during inflammatory disorders. | Sagar, P., et al. 2021. Pharmacol Ther. 226: 107877. PMID: 33895185
- Hepcidin Protects Yellow Catfish (Pelteobagrus fulvidraco) against Aeromonas veronii-Induced Ascites Disease by Regulating Iron Metabolism. | Fu, M., et al. 2021. Antibiotics (Basel). 10: PMID: 34356769
- Fursultiamine Prevents Drug-Induced Ototoxicity by Reducing Accumulation of Reactive Oxygen Species in Mouse Cochlea. | Kim, YR., et al. 2021. Antioxidants (Basel). 10: PMID: 34679662
Inhibitor of:
DHRS6, and SRF.Activator of:
Oxytocin-R, and Tpk1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fursultiamine, 25 mg | sc-495854 | 25 mg | $265.00 | |||
Fursultiamine, 100 mg | sc-495854A | 100 mg | $622.00 |