Molecular structure of Furegrelate Sodium (U-63557A), CAS Number: 85666-17-7
Furegrelate Sodium (U-63557A) (CAS 85666-17-7)
Application:
Furegrelate Sodium (U-63557A) is a selective and potent thromboxane A2 synthase (TXA2R) inhibitor in platelets
CAS Number:
85666-17-7
Purity:
≥98%
Molecular Weight:
275.2
Molecular Formula:
C15H10NO3•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Furegrelate Sodium (U-63557A) is a selective and potent TXA Synthase (thromboxane A2 synthase) inhibitor in platelets. It has been shown to inhibit platelet aggregation. Furegrelate Sodium (U-63557A) has been found to inhibit TXB2 formation from PGH2 in a concentration dependent manner in human platelet rich plasma (PRP). It has also been found to inhibit arachidonic acid thromboxane B2 formation in human PRP.
Furegrelate Sodium (U-63557A) (CAS 85666-17-7) References
- Thromboxane A(2) limits differentiation and enhances apoptosis of cultured human trophoblasts. | Yusuf, K., et al. 2001. Pediatr Res. 50: 203-9. PMID: 11477204
- Inhibition of prostaglandin synthesis during polystyrene microsphere-induced pulmonary embolism in the rat. | Jones, AE., et al. 2003. Am J Physiol Lung Cell Mol Physiol. 284: L1072-81. PMID: 12639842
- Inhibition of cyclooxygenase metabolite production attenuates ischemia-reperfusion lung injury. | Ljungman, AG., et al. 1991. Am Rev Respir Dis. 143: 610-7. PMID: 1900402
- Furegrelate, a thromboxane synthase inhibitor, blunts the development of pulmonary arterial hypertension in neonatal piglets. | Hirenallur-S, DK., et al. 2012. Pulm Circ. 2: 193-200. PMID: 22837860
- Multiple dose trial of the thromboxane synthase inhibitor furegrelate in normal subjects. | Mohrland, JS., et al. 1990. Eur J Clin Pharmacol. 38: 485-8. PMID: 2379533
- Attenuated coronary relaxation after reperfusion: effects of superoxide dismutase and TxA2 inhibitor U 63557A. | Mehta, JL., et al. 1989. Am J Physiol. 257: H1240-6. PMID: 2552841
- Thromboxane synthase activity and platelet function after furegrelate administration in man. | Mohrland, JS., et al. 1989. J Clin Pharmacol. 29: 53-8. PMID: 2708549
- Mediators of C5a-induced bronchoconstriction. | Regal, JF. 1987. Agents Actions. 21: 363-5. PMID: 2825486
- Thromboxane synthesis inhibitors and postprandial jejunal capillary exchange capacity. | Mangino, MJ. and Chou, CC. 1988. Am J Physiol. 254: G695-701. PMID: 3364569
- Sodium 5-(3'-pyridinylmethyl)benzofuran-2-carboxylate (U-63557A) potentiates protective effect of intravenous eicosapentaenoic acid on impaired CBF in ischemic gerbils. | Black, KL., et al. 1984. J Neurosurg. 61: 453-7. PMID: 6086857
- Inhibition of platelet thromboxane A2 synthase activity by sodium 5-(3'-pyridinylmethyl)benzofuran-2-carboxylate. | Gorman, RR., et al. 1983. Prostaglandins. 26: 325-42. PMID: 6316421
- Inhibitors of cyclooxygenases produce amnesia for a passive avoidance task in the chick. | Hölscher, C. 1995. Eur J Neurosci. 7: 1360-5. PMID: 7582110
- Acquired essential fatty acid depletion in the remnant kidney: amelioration with U-63557A. | Schmitz, PG., et al. 1994. Kidney Int. 46: 1184-91. PMID: 7861715
Inhibitor of:
TXA Synthase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Furegrelate Sodium (U-63557A), 10 mg | sc-200705 | 10 mg | $129.00 | |||
Furegrelate Sodium (U-63557A), 50 mg | sc-200705A | 50 mg | $400.00 |