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FURA 2/AM (CAS 108964-32-5) - chemical structure image
Molecular structure of FURA 2/AM, CAS Number: 108964-32-5
FURA 2/AM (CAS 108964-32-5) - chemical structure image
Molecular structure of FURA 2/AM, CAS Number: 108964-32-5
FURA 2/AM: sc-203052
FURA 2/AM: sc-203052
Molecular structure of FURA 2/AM, CAS Number: 108964-32-5

FURA 2/AM (CAS 108964-32-5)

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Alternate Names:
FURA 2/AM also known as FURA-2AM; Acid Pentaacetoxymethyl Ester; Fura-2 pentakis(acetoxymethyl) ester; C44-H47-N3-O24; chelator/ sequestrant
Application:
FURA 2/AM is the cell-permeable ester form of FURA 2 which is highly selective Ca2+ fluorescent chelator
CAS Number:
108964-32-5
Molecular Weight:
1001.85
Molecular Formula:
C44H47N3O24
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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SDS & Certificate of Analysis

FURA 2/AM is the cell-permeable ester form of FURA 2 (sc-221644 sc-202163), which is a fluorescent chelator (Kd = 224 nM) selective for Ca2+ over other ions and offers 30 times greater fluorescence intensity than QUIN 2 (sc-202303). FURA 2/AM is rapidly metabolized in the cell by cytoplasmic esterases yielding the active dye FURA 2. It can be used as a probe to determine calcium concentrations in many cellular systems, including: cardiac myocytes, vascular smooth muscle cells, and medullary collecting tubules. Spectral properties in the presence of low calcium concentrations (excitation max = 362 nm, emission max = 512 nm) differ from those during high calcium conditions (excitation max = 335 nm, emission max = 505 nm).


FURA 2/AM (CAS 108964-32-5) References

  1. [Compared study on Fura-2/AM assay and MTT assay for screening multidrug resistant modulators].  |  Fu, LW., et al. 1997. Yao Xue Xue Bao. 32: 401-5. PMID: 11596320
  2. Stretch-induced increases in intracellular calcium of isolated vascular smooth muscle cells.  |  Davis, MJ., et al. 1992. Am J Physiol. 263: H1292-9. PMID: 1329564
  3. Calcium imaging of cortical neurons using Fura-2 AM.  |  Barreto-Chang, OL. and Dolmetsch, RE. 2009. J Vis Exp.. PMID: 19229178
  4. Enhanced loading of Fura-2/AM calcium indicator dye in adult rodent brain slices via a microfluidic oxygenator.  |  Mauleon, G., et al. 2013. J Neurosci Methods. 216: 110-7. PMID: 23608309
  5. Loading of fura-2/AM with an aid of DFP on single smooth muscle cells prepared from guinea pig taenia coli.  |  Maruyama, I., et al. 1989. J Pharmacol Methods. 21: 1-12. PMID: 2495388
  6. Incomplete hydrolysis of the calcium indicator precursor fura-2 pentaacetoxymethyl ester (fura-2 AM) by cells.  |  Oakes, SG., et al. 1988. Anal Biochem. 169: 159-66. PMID: 3369679
  7. A Spectrofluorophotometrical Method Based on Fura-2-AM Probe to Determine Cytosolic Ca2+ Level in Pseudomonas syringae Complex Bacterial Cells.  |  Trabalza, S., et al. 2021. Bio Protoc. 11: e3949. PMID: 33855111
  8. Measurement of the Intracellular Calcium Concentration with Fura-2 AM Using a Fluorescence Plate Reader.  |  Martínez, M., et al. 2017. Bio Protoc. 7: e2411. PMID: 34541141
  9. Effect of DFP on loading of fura 2/AM and quin 2/AM into single smooth muscle cells prepared from guinea pig taenia coli.  |  Maruyama, I., et al. 1987. FEBS Lett. 220: 89-92. PMID: 3609323
  10. Intracellular Ca2+ transients in isolated perfused rat heart: measurement using the fluorescent indicator Fura-2/AM.  |  Field, ML., et al. 1994. Cell Calcium. 16: 87-100. PMID: 7982268
  11. The source of epifluorescence in isolated perfused heart loaded with fura 2-AM or indo 1-AM.  |  Shinozaki, T., et al. 1993. Heart Vessels. 8: 79-84. PMID: 8314741
  12. Intracellular concentrations of fura-2 and fura-2/am in vascular smooth muscle cells following perfusion loading of fura-2/am in arterial segments.  |  Tran, NN., et al. 1995. Cell Calcium. 18: 420-8. PMID: 8581970
  13. Use of fura-2/AM to measure intracellular free calcium in Selenomonas ruminantium.  |  Nakamura, I., et al. 1996. Tohoku J Exp Med. 179: 291-4. PMID: 8944431
  14. Effects of tetrandrine, Fura 2-AM, and Bay k 8644 on platelet-activating factor release from rat peritoneal macrophages stimulated by lipopolysaccharides.  |  Song, SQ. and Hu, YM. 1996. Zhongguo Yao Li Xue Bao. 17: 230-2. PMID: 9812743

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

FURA 2/AM, 50 µg

sc-203052
50 µg
$32.00

FURA 2/AM, 1 mg

sc-203052A
1 mg
$146.00

FURA 2/AM, 50 mg

sc-203052B
50 mg
$3874.00

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. FURA 2/AM, sc-203052, is a yellow solid.
Answered by: Chemical Support 4
Date published: 2017-03-08
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Rated 5 out of 5 by from Great features!Excellent service with kind personel, and products are very good.
Date published: 2022-01-28
Rated 4 out of 5 by from great productI used to purchase from other vendor. I shifted to this product because of cost and found it is great. Highly recommended
Date published: 2017-05-18
Rated 5 out of 5 by from Hung TY; etHung TY; et. Al, (PubMed ID: 26387654) utilized FURA 2/AM (a fluorescent dye commonly used to measure Ca2+ concentration) to interpret the effect of Safrole on free cystolic Ca2+. -SCBT Publication Review
Date published: 2015-06-27
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FURA 2/AM is rated 4.7 out of 5 by 3.
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