Fumagillol (CAS 108102-51-8)
CAS Number:
108102-51-8
Molecular Weight:
282.38
Molecular Formula:
C16H26O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Fumagillol is a spiro-epoxide, secondary alcohol, and sesquiterpenoid with antimicrobial properties. It is derived from the fungus Aspergillus fumigatus and has been studied for its various biological activities and potential applications. It exhibits anti-angiogenic, anti-parasitic, and anti-inflammatory properties. Fumagillol can also inhibit the activity of certain enzymes, particularly metalloproteinases and methionine aminopeptidases. These enzymes are involved in various biological processes, including cell migration, tissue remodeling, and protein metabolism.
Fumagillol (CAS 108102-51-8) References
- Design and synthesis of highly potent fumagillin analogues from homology modeling for a human MetAP-2. | Han, CK., et al. 2000. Bioorg Med Chem Lett. 10: 39-43. PMID: 10636239
- Concise stereocontrolled routes to fumagillol, fumagillin, and TNP-470. | Vosburg, DA., et al. 2003. Chirality. 15: 156-66. PMID: 12520508
- Chemical modification of fumagillin. I. 6-O-acyl, 6-O-sulfonyl, 6-O-alkyl, and 6-O-(N-substituted-carbamoyl)fumagillols. | Marui, S., et al. 1992. Chem Pharm Bull (Tokyo). 40: 96-101. PMID: 1374294
- Chemical modification of fumagillin. II. 6-Amino-6-deoxyfumagillol and its derivatives. | Marui, S. and Kishimoto, S. 1992. Chem Pharm Bull (Tokyo). 40: 575-9. PMID: 1377100
- Degradation of target protein in living cells by small-molecule proteolysis inducer. | Zhang, D., et al. 2004. Bioorg Med Chem Lett. 14: 645-8. PMID: 14741260
- 5-Demethoxyfumagillol, a potent angiogenesis inhibitor isolated from Aspergillus fumigatus. | Kim, D., et al. 2004. Chem Pharm Bull (Tokyo). 52: 447-50. PMID: 15056962
- Total synthesis and antiangiogenic activity of cyclopentane analogues of fumagillol. | Jeong, BS., et al. 2005. Bioorg Med Chem Lett. 15: 3580-3. PMID: 15978809
- [Inhibitory effect of fumagillol combined with cyclophosphamide on metastasis of lung adenocarcinoma cell line LA795 xenograft in mice]. | Wang, XH., et al. 2005. Ai Zheng. 24: 1448-52. PMID: 16351790
- Design, synthesis, and antiangiogenic effects of a series of potent novel fumagillin analogues. | Lee, HW., et al. 2007. Chem Pharm Bull (Tokyo). 55: 1024-9. PMID: 17603194
- Spectroscopic detection of pharmaceutical compounds from an aflatoxigenic strain of Aspergillus parasiticus. | Basaran, P. and Demirbas, RM. 2010. Microbiol Res. 165: 516-22. PMID: 19879117
- Diazo reagents with small steric footprints for simultaneous arming/SAR studies of alcohol-containing natural products via O-H insertion. | Chamni, S., et al. 2011. ACS Chem Biol. 6: 1175-81. PMID: 21894934
- Remodelling of the natural product fumagillol employing a reaction discovery approach. | Balthaser, BR., et al. 2011. Nat Chem. 3: 969-73. PMID: 22213919
- Remodeling of fumagillol: discovery of an oxygen-directed oxidative Mannich reaction. | Grenning, AJ., et al. 2014. Org Lett. 16: 792-5. PMID: 24410175
- Stability of dicyclohexylamine and fumagillin in honey. | van den Heever, JP., et al. 2015. Food Chem. 179: 152-8. PMID: 25722149
- Anti-angiogenic Nanotherapy Inhibits Airway Remodeling and Hyper-responsiveness of Dust Mite Triggered Asthma in the Brown Norway Rat. | Lanza, GM., et al. 2017. Theranostics. 7: 377-389. PMID: 28042341
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fumagillol, 0.5 mg | sc-489510 | 0.5 mg | $533.00 |