FTI-277 trifluoroacetate salt CAS: 170006-73-2 (free base)
MF: C22H29N3O3S2•xC2HF3O2
MW: 447.61
A peptidomimetic farnesyl transferase inhibitor.

FTI-277 trifluoroacetate salt (CAS 170006-73-2 (free base))

FTI-277 trifluoroacetate salt | CAS 170006-73-2 (free base) is rated 5.0 out of 5 by 1.
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Application: A peptidomimetic farnesyl transferase inhibitor
CAS Number: 170006-73-2 (free base)
Purity: ≥95%
Molecular Weight: 447.61
Molecular Formula: C22H29N3O3S2•xC2HF3O2
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

FTI-277 trifluoroacetate salt is an inhibitor of farnesyl transferase (FTase). Studies show the compound to be a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling.


References

1. Cohen-Jonathan, E., et al., 1999. The farnesyltransferase inhibitor FTI-277 suppresses the 24-kDa FGF2-induced radioresistance in HeLa cells expressing wild-type RAS. Radiation research. 152(4): 404-11. PMID: 10477917

Appearance :
Amorphous
Physical State :
Solid
Solubility :
Soluble in Water: ≥2 mg/mL
Storage :
Store at -80° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
MDL Number :
MFCD06795840
SMILES :
CSCC[[email protected]](NC(=O)C1CCC(NC[[email protected]@H](N)CS)CC1C1CCCCC1)C(=O)OC.OC(=O)C(F)(F)F

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Certificate of Analysis

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FTI-277 trifluoroacetate salt  Product Citations

See how others have used FTI-277 trifluoroacetate salt. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 31956834  ACS Omega. 5: 832-842.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Yang W; et al Yang W; et al. (PubMed ID: 21873557) determined that FTI-277 trifluoroacetate salt induced improvement in survival of septic mice and blocked the increase in farnesylated proteins mice. -SCBT Publication Review
Date published: 2015-01-31
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