FTI-277 trifluoroacetate salt is an inhibitor of farnesyl transferase (FTase). Studies show the compound to be a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling.
1. Cohen-Jonathan, E., et al., 1999. The farnesyltransferase inhibitor FTI-277 suppresses the 24-kDa FGF2-induced radioresistance in HeLa cells expressing wild-type RAS. Radiation research. 152(4): 404-11. PMID: 10477917
Soluble in Water: ≥2 mg/mL
Store at -80° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Rated 5 out of
Yang W; et alYang W; et al. (PubMed ID: 21873557) determined that FTI-277 trifluoroacetate salt induced improvement in survival of septic mice and blocked the increase in farnesylated proteins mice. -SCBT Publication Review
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