Molecular structure of FTase Inhibitor I, CAS Number: 149759-96-6
FTase Inhibitor I (CAS 149759-96-6)
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Alternate Names:
B581
Application:
FTase Inhibitor I is a potent, selective, peptidomimetic FTase inhibitor
CAS Number:
149759-96-6
Purity:
≥95%
Molecular Weight:
470.69
Molecular Formula:
C22H38N4O3S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
FTase Inhibitor I is a potent, cell-permeable, selective, peptidomimetic inhibitor of Farnesyl Transferase (FTase). It is ~37-fold more active against Farnesyl Transferase (FTase) than against GGTase (geranylgeranyltransferase). Is also very resistant to proteolysis.
FTase Inhibitor I (CAS 149759-96-6) References
- Perillyl alcohol, an inhibitor of geranylgeranyl transferase, induces apoptosis of immortalized human vascular smooth muscle cells in vitro. | Unlu, S., et al. 2000. J Cardiovasc Pharmacol. 35: 341-4. PMID: 10672871
- Cell-cycle-dependent activation of mitogen-activated protein kinase kinase (MEK-1/2) in myeloid leukemia cell lines and induction of growth inhibition and apoptosis by inhibitors of RAS signaling. | Morgan, MA., et al. 2001. Blood. 97: 1823-34. PMID: 11238126
- Fumarylacetoacetate, the metabolite accumulating in hereditary tyrosinemia, activates the ERK pathway and induces mitotic abnormalities and genomic instability. | Jorquera, R. and Tanguay, RM. 2001. Hum Mol Genet. 10: 1741-52. PMID: 11532983
- Ras protein contributes to cerebral vasospasm in a canine double-hemorrhage model. | Yamaguchi, M., et al. 2004. Stroke. 35: 1750-5. PMID: 15143294
- Analysis of the eukaryotic prenylome by isoprenoid affinity tagging. | Nguyen, UT., et al. 2009. Nat Chem Biol. 5: 227-35. PMID: 19219049
- Regulation of endoplasmic reticulum stress and trophectoderm lineage specification by the mevalonate pathway in the mouse preimplantation embryo. | Marikawa, Y., et al. 2021. Mol Hum Reprod. 27: PMID: 33677573
- The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation. | Cox, AD., et al. 1994. J Biol Chem. 269: 19203-6. PMID: 8034681
- Peptidomimetic inhibitors of Ras farnesylation and function in whole cells. | Garcia, AM., et al. 1993. J Biol Chem. 268: 18415-8. PMID: 8360140
- Cripto-1 inhibits beta-casein expression in mammary epithelial cells through a p21ras-and phosphatidylinositol 3'-kinase-dependent pathway. | De Santis, ML., et al. 1997. Cell Growth Differ. 8: 1257-66. PMID: 9419414
- Insulin regulation of glucose-6-phosphate dehydrogenase gene expression is rapamycin-sensitive and requires phosphatidylinositol 3-kinase. | Wagle, A., et al. 1998. J Biol Chem. 273: 14968-74. PMID: 9614103
Inhibitor of:
Farnesyl Transferase, and GGTase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FTase Inhibitor I, 1 mg | sc-221632 | 1 mg | $208.00 |