Molecular structure of FSCPX, CAS Number: 156547-56-7
FSCPX (CAS 156547-56-7)
See product citations (2)
Alternate Names:
8-cyclopentyl-3-(3-((4-(fluorosulfonyl)benzoyl)oxy)propyl)-1-propylxanthine
Application:
FSCPX is an irreversible Adenosine A1-R (A1 adenosine receptor) antagonist
CAS Number:
156547-56-7
Molecular Weight:
506.55
Molecular Formula:
C23H27FN4O6S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
FSCPX is an irreversible Adenosine A1-R (A1 adenosine receptor) antagonist. FSCPX, a highly powerful and specific irreversible antagonist of the A1 adenosine receptor (A1AR), exhibits exceptional affinity for binding to the A1AR in the low nanomolar range. This compound, when utilized, effectively alters the impact of NBTI, a nucleoside transport inhibitor, by decreasing the interstitial adenosine level in the guinea pig atrium.
FSCPX (CAS 156547-56-7) References
- Differential A(1)-adenosine receptor reserve for inhibition of cyclic AMP accumulation and G-protein activation in DDT(1) MF-2 cells. | Baker, SP., et al. 2000. Br J Pharmacol. 130: 1156-64. PMID: 10882402
- Synthesis and use of FSCPX, an irreversible adenosine A1 antagonist, as a 'receptor knock-down' tool. | van Muijlwijk-Koezen, JE., et al. 2001. Bioorg Med Chem Lett. 11: 815-8. PMID: 11277527
- New irreversible adenosine A(1) antagonists based on FSCPX. | Beauglehole, AR., et al. 2002. Bioorg Med Chem Lett. 12: 3179-82. PMID: 12372528
- Activation of adenosine low-affinity A3 receptors inhibits the enteric short interplexus neural circuit triggered by histamine. | Bozarov, A., et al. 2009. Am J Physiol Gastrointest Liver Physiol. 297: G1147-62. PMID: 19808660
- The surmountable effect of FSCPX, an irreversible A(1) adenosine receptor antagonist, on the negative inotropic action of A(1) adenosine receptor full agonists in isolated guinea pig left atria. | Gesztelyi, R., et al. 2013. Arch Pharm Res. 36: 293-305. PMID: 23456693
- The guinea pig atrial A1 adenosine receptor reserve for the direct negative inotropic effect of adenosine. | Kiss, Z., et al. 2013. Gen Physiol Biophys. 32: 325-35. PMID: 23817640
- FSCPX, a Chemical Widely Used as an Irreversible A₁ Adenosine Receptor Antagonist, Modifies the Effect of NBTI, a Nucleoside Transport Inhibitor, by Reducing the Interstitial Adenosine Level in the Guinea Pig Atrium. | Erdei, T., et al. 2018. Molecules. 23: PMID: 30200192
- A Body of Circumstantial Evidence for the Irreversible Ectonucleotidase Inhibitory Action of FSCPX, an Agent Known as a Selective Irreversible A1 Adenosine Receptor Antagonist So Far. | Viczjan, G., et al. 2021. Int J Mol Sci. 22: PMID: 34575993
- Differential A1 adenosine receptor reserve for two actions of adenosine on guinea pig atrial myocytes. | Srinivas, M., et al. 1997. Mol Pharmacol. 52: 683-91. PMID: 9380032
Inhibitor of:
Adenosine A1-R.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FSCPX, 5 mg | sc-252841A | 5 mg | $369.00 | |||
FSCPX, 25 mg | sc-252841 | 25 mg | $1436.00 |