FRA10AC1 Antibody (732.1): sc-81858
- FRA10AC1 Antibody (732.1) is a mouse monoclonal IgG1 κ FRA10AC1 antibody provided at 50 µg/0.5 ml
- raised against recombinant FRA10AC1 of human origin
- recommended for detection of FRA10AC1 of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for FRA10AC1 Antibody (732.1). This work is in progress.
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FRA10AC1 Antibody (732.1) is a mouse monoclonal IgG1 kappa light chain antibody that detects FRA10AC1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-FRA10AC1 antibody (732.1) is available as the non-conjugated format. FRA10AC1 protein, also known as C10orf4 (chromosome 10 open reading frame 4), is a crucial 315 amino acid nuclear protein predominantly expressed in kidney, liver, heart, brain, and skeletal muscle. Nuclear localization of FRA10AC1 plays a vital role in regulating gene expression and cellular responses to stress. Defects in C10orf4 can lead to an expansion of a polymorphic CGG repeat within the 5′-untranslated region, associated with expression of the folate-sensitive fragile site FRA10A. Aberrant expression of FRA10A has been linked to various health issues, including tumorigenesis, neurological disorders, and mental retardation. C10orf4 is conserved across species, highlighting fundamental biological importance. FRA10AC1 exists in five isoforms, all resulting from alternative splicing events that alter C-termini, which may contribute to diverse functional roles in cellular processes.
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FRA10AC1 Antibody (732.1) References:
- Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs. | Yu, Y., et al. 2001. Genome Res. 11: 1392-403. PMID: 11483580
- The DNA sequence and comparative analysis of human chromosome 10. | Deloukas, P., et al. 2004. Nature. 429: 375-81. PMID: 15164054
- Folate-sensitive fragile site FRA10A is due to an expansion of a CGG repeat in a novel gene, FRA10AC1, encoding a nuclear protein. | Sarafidou, T., et al. 2004. Genomics. 84: 69-81. PMID: 15203205
- Chromatin structure of human chromosomal fragile sites. | Wang, YH. 2006. Cancer Lett. 232: 70-8. PMID: 16229940
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FRA10AC1 Antibody (732.1) | sc-81858 | 50 µg/0.5 ml | $316.00 |