FR 900098 Monosodium Salt (CAS 73226-73-0)
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FR 900098 Monosodium Salt is a compound used as a research tool in the study of metabolic pathways, specifically those involved in the synthesis of isoprenoids. This compound is known to inhibit the enzyme 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR), a key enzyme in the non-mevalonate pathway of isoprenoid biosynthesis, which is present in many bacteria, apicomplexan parasites, and plants. Researchers utilize FR 900098 Monosodium Salt to study the effects of DXR inhibition on the growth and survival of various organisms that rely on the non-mevalonate pathway for the production of essential terpenoids. The compound′s inhibitory action helps to elucidate the role of isoprenoids in cellular processes and can be used to explore potential targets for new antimicrobial compounds. Additionally, FR 900098 Monosodium Salt is valuable in plant science research, where it is used to investigate the importance of the non-mevalonate pathway in plant development and stress responses. Its role as a monosodium salt enhances its solubility, facilitating its use in various experimental conditions.
FR 900098 Monosodium Salt (CAS 73226-73-0) References
- FR-900098, an antimalarial development candidate that inhibits the non-mevalonate isoprenoid biosynthesis pathway, shows no evidence of acute toxicity and genotoxicity. | Wiesner, J., et al. 2016. Virulence. 7: 718-28. PMID: 27260413
- Utilization of an intermediate of the methylerythritol phosphate pathway, (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate, as the prenyl donor substrate for various prenyltransferases. | Hayashi, Y., et al. 2018. Biosci Biotechnol Biochem. 82: 993-1002. PMID: 29191109
- Studies on new phosphonic acid antibiotics. I. FR-900098, isolation and characterization. | Okuhara, M., et al. 1980. J Antibiot (Tokyo). 33: 13-7. PMID: 6768704
- Studies on phosphonic acid antibiotics. I. Structure and synthesis of 3-(n-acetyl-n-hydroxyamino)propylphosphonic acid (FR-900098) and its n-formyl analogue (FR-31564) | Takashi Kamiya ∗, Keiji Hemmi, Hidekazu Takeno, Masashi Hashimoto. 1980. Tetrahedron Letters. 21: 95-98.
- Combinatorial Effects of Monensin in Liposome Formulations with Antimalarial Drugs Against Blood Stages of Plasmodium falciparum in Culture and P. berghei Infection | Rajendran, V., Pachauri, M., & Ghosh, P. C. 2018. Current Drug Therapy. 13(1): 74-82.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FR 900098 Monosodium Salt, 10 mg | sc-207703 | 10 mg | $345.00 |