FOXR2 Antibody (2C1): sc-517037

FOXR2 Antibody (2C1) is a mouse monoclonal IgG1 kappa light chain antibody that detects the FOXR2 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-FOXR2 antibody (2C1) is available as the non-conjugated format. The Forkhead-box (FOX) genes comprise a superfamily of at least 43 members that express proteins involved in transcriptional regulation and may be associated with the pathogenesis of various cancers. FOXR2, also known as Forkhead box protein R2 or FOXN6, is a 311 amino acid nuclear protein that belongs to the FOX family and contains one fork-head DNA-binding domain. FOXR2 plays a crucial role in regulating gene expression, particularly in the context of cancer, where FOXR2 is often overexpressed. The significance of FOXR2′s function lies in its ability to influence cellular processes such as proliferation and differentiation, which are critical in tumorigenesis. Notably, FOXR2 is not abundantly expressed in normal tissues but is found at very high levels in breast cancer and primary cancer cell lines, suggesting FOXR2′s potential as a biomarker for aggressive forms of cancer. Through chromosomal aberrations such as retroviral integration, gene amplification, or translocation, FOXR2 may contribute to the development of certain invasive carcinomas, making FOXR2 a target of interest for therapeutic interventions and research into cancer biology.

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FOXR2 Antibody (2C1) References:

1. Identification and characterization of human FOXN6, mouse Foxn6, and rat Foxn6 genes in silico.  |  Katoh, M. and Katoh, M. 2004. Int J Oncol. 25: 219-23. PMID: 15202009
2. Identification and characterization of human FOXK1 gene in silico.  |  Katoh, M. and Katoh, M. 2004. Int J Mol Med. 14: 127-32. PMID: 15202027
3. Germ-line mutation of Foxn5 gene in mouse lineage.  |  Katoh, M. and Katoh, M. 2004. Int J Mol Med. 14: 463-7. PMID: 15289901
4. Human FOX gene family (Review).  |  Katoh, M. and Katoh, M. 2004. Int J Oncol. 25: 1495-500. PMID: 15492844
5. Characterization of human FOXN4 gene in silico.  |  Katoh, M. and Katoh, M. 2004. Int J Mol Med. 14: 949-53. PMID: 15492871

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FOXR2 Antibody (2C1) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-FOXR2 Antibody (2C1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FOXR2 Antibody (2C1) Specifications

Alternate Product Name: FOXR2

Product Clone Name: 2C1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-311

Epitope Target: FOXR2

Epitope Species: human

Product Reactivity/Detection: FOXR2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for FOXR2 Antibody (2C1): N/A