FOXM1 Antibody (A-11): sc-271746

FOXM1 Antibody (A-11) is a mouse monoclonal IgG2a kappa light chain antibody designed to detect all isoforms of FOXM1 across mouse, rat, and human species using applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-FOXM1 antibody (A-11) targets an epitope mapping between amino acids 737-763 at the C-terminus of human FOXM1, ensuring precise binding and reliable detection. Forkhead box M1 (FOXM1), also called FKHL16, HFH11, INS-1, and PIG29, is a critical transcription factor located predominantly in the nucleus of proliferating cells, where FOXM1 plays an essential role in regulating the expression of genes involved in cell cycle progression, particularly the transition from G1 to S phase and mitotic entry by activating key cell cycle regulators like cyclin B1, cyclin D1, and Cdc25B. Nuclear localization of FOXM1 is vital for controlling cellular proliferation, DNA replication, and repair processes, making FOXM1 a key player in maintaining normal cell growth and tissue regeneration. Dysregulation of FOXM1, often resulting in overexpression, is closely associated with various cancers, as FOXM1 can lead to uncontrolled cell division and tumor progression. Additionally, FOXM1 undergoes alternative splicing to produce isoforms such as FOXM1A and FOXM1B, which have distinct roles in protein stability and function, influencing processes like cellular aging and hepatocyte DNA replication. FOXM1 monoclonal antibody (A-11) is available in both non-conjugated form and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for diverse experimental needs. FOXM1 (A-11) antibody enables researchers to effectively investigate the intricate mechanisms of FOXM1 in both normal and pathological states, facilitating advancements in understanding and targeting proliferative diseases.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

FOXM1 Antibody (A-11) References:

1. Mitotic misregulation and human aging.  |  Ly, DH., et al. 2000. Science. 287: 2486-92. PMID: 10741968
2. Increased levels of forkhead box M1B transcription factor in transgenic mouse hepatocytes prevent age-related proliferation defects in regenerating liver.  |  Wang, X., et al. 2001. Proc Natl Acad Sci U S A. 98: 11468-73. PMID: 11572993
3. The Forkhead Box m1b transcription factor is essential for hepatocyte DNA replication and mitosis during mouse liver regeneration.  |  Wang, X., et al. 2002. Proc Natl Acad Sci U S A. 99: 16881-6. PMID: 12482952
4. Hepatocyte nuclear factor 3/fork head homolog 11 is expressed in proliferating epithelial and mesenchymal cells of embryonic and adult tissues.  |  Ye, H., et al. 1997. Mol Cell Biol. 17: 1626-41. PMID: 9032290
5. Molecular analysis of a novel winged helix protein, WIN. Expression pattern, DNA binding property, and alternative splicing within the DNA binding domain.  |  Yao, KM., et al. 1997. J Biol Chem. 272: 19827-36. PMID: 9242644
6. The human TRIDENT/HFH-11/FKHL16 gene: structure, localization, and promoter characterization.  |  Korver, W., et al. 1997. Genomics. 46: 435-42. PMID: 9441747

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FOXM1 Antibody (A-11) has 37 citations in a variety of scientific publications.

Primary antibodies like Anti-FOXM1 Antibody (A-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FOXM1 Antibody (A-11) Specifications

Alternate Product Name: forkhead box FOXM1

Product Clone Name: A-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 737-763

Epitope Target: FOXM1

Epitope Species: human

Product Reactivity/Detection: all isoforms of FOXM1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 37 citations in various scientific publications

Available Conjugates/Forms for FOXM1 Antibody (A-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin