FOXL1 Antibody (40-M): sc-130373

FOXL1 Antibody (40-M) is a mouse monoclonal IgG2b kappa light chain antibody that detects FOXL1 protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-FOXL1 antibody (40-M) is available as a non-conjugated monoclonal isotype antibody. FOXL1, consisting of 337 amino acids, is encoded by the mouse gene Foxl1 and belongs to the forkhead family, characterized by a distinct forkhead DNA-binding domain. This family of transcription factors plays crucial roles in various biological processes, including development and cellular differentiation. FOXL1 functions as a winged helix transcriptional regulator expressed in the mesenchymal layer of both developing and mature gastrointestinal tract. FOXL1 maintains gut-associated structures, such as Peyer′s patches, which are essential for immune response in the small intestine. FOXL1-deficient mice exhibit significant defects in the epithelial layer of the gastrointestinal tract and gut-associated lymphoid tissues, highlighting FOXL1′s critical role in gastrointestinal health and tumorigenesis. Additionally, FOXL1 acts as a mesenchymal modifier of the Adenomatous Polyposis Coli (APC) gene products, underscoring FOXL1′s importance in gastrointestinal tumor development.

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FOXL1 Antibody (40-M) References:

1. Foxl1 controls the Wnt/beta-catenin pathway by modulating the expression of proteoglycans in the gut.  |  Perreault, N., et al. 2001. J Biol Chem. 276: 43328-33. PMID: 11555641
2. Mesenchymal expression of Foxl1, a winged helix transcriptional factor, regulates generation and maintenance of gut-associated lymphoid organs.  |  Fukuda, K., et al. 2003. Dev Biol. 255: 278-89. PMID: 12648490
3. Phylogenetic relationships of the Fox (Forkhead) gene family in the Bilateria.  |  Mazet, F., et al. 2003. Gene. 316: 79-89. PMID: 14563554
4. Foxl1 null mice have abnormal intestinal epithelia, postnatal growth retardation, and defective intestinal glucose uptake.  |  Katz, JP., et al. 2004. Am J Physiol Gastrointest Liver Physiol. 287: G856-64. PMID: 15155178
5. Foxl1 is a mesenchymal Modifier of Min in carcinogenesis of stomach and colon.  |  Perreault, N., et al. 2005. Genes Dev. 19: 311-5. PMID: 15650110
6. Foxl1-deficient mice exhibit aberrant epithelial cell positioning resulting from dysregulated EphB/EphrinB expression in the small intestine.  |  Takano-Maruyama, M., et al. 2006. Am J Physiol Gastrointest Liver Physiol. 291: G163-70. PMID: 16469829
7. Six members of the mouse forkhead gene family are developmentally regulated.  |  Kaestner, KH., et al. 1993. Proc Natl Acad Sci U S A. 90: 7628-31. PMID: 7689224
8. Clustered arrangement of winged helix genes fkh-6 and MFH-1: possible implications for mesoderm development.  |  Kaestner, KH., et al. 1996. Development. 122: 1751-8. PMID: 8674414

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FOXL1 Antibody (40-M) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-FOXL1 Antibody (40-M) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FOXL1 Antibody (40-M) Specifications

Alternate Product Name: FOXL1

Product Clone Name: 40-M

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 132-240

Epitope Target: FOXL1

Epitope Species: human

Product Reactivity/Detection: FOXL1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for FOXL1 Antibody (40-M): N/A