FOXD3 Antibody (5G9B10): sc-517206
- FOXD3 Antibody (5G9B10) is a mouse monoclonal IgG1 κ FOXD3 antibody, cited in 5 publications, provided at 50 µl ascites
- raised against a recombinant protein corresponding to amino acids 132-293 of FOXD3 of human origin
- recommended for detection of FOXD3 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for FOXD3 Antibody (5G9B10). This work is in progress.
FOXD3 Antibody (5G9B10) is a mouse monoclonal IgG1 kappa light chain antibody that detects FOXD3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-FOXD3 antibody (5G9B10) is available as a non-conjugated format. FOXD3 plays a crucial role in regulating embryonic stem cell pluripotency and is essential for maintaining undifferentiated states in these cells. FOXD3 functions as a transcriptional regulator, and FOXD3 expression is tightly controlled during development; while FOXD3 is generally downregulated after gastrulation, FOXD3 remains active in the neural crest. FOXD3′s ability to interact with various growth factors, such as FGF8 and SNAIL, is vital for sustaining the undifferentiated state of embryonic stem cells, and defects in FOXD3 induction can lead to premature differentiation and migration-related birth defects. FOXD3 serves as a key player in early development and a significant factor in understanding developmental disorders and potential therapeutic targets.
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FOXD3 Antibody (5G9B10) References:
- The embryonic stem cell transcription factors Oct-4 and FoxD3 interact to regulate endodermal-specific promoter expression. | Guo, Y., et al. 2002. Proc Natl Acad Sci U S A. 99: 3663-7. PMID: 11891324
- Requirement for Foxd3 in maintaining pluripotent cells of the early mouse embryo. | Hanna, LA., et al. 2002. Genes Dev. 16: 2650-61. PMID: 12381664
- Snail precedes slug in the genetic cascade required for the specification and migration of the Xenopus neural crest. | Aybar, MJ., et al. 2003. Development. 130: 483-94. PMID: 12490555
- Neural crest induction by paraxial mesoderm in Xenopus embryos requires FGF signals. | Monsoro-Burq, AH., et al. 2003. Development. 130: 3111-24. PMID: 12783784
- Neural crest cells: a model for invasive behavior. | Tucker, RP. 2004. Int J Biochem Cell Biol. 36: 173-7. PMID: 14643882
- Differences between human and mouse embryonic stem cells. | Ginis, I., et al. 2004. Dev Biol. 269: 360-80. PMID: 15110706
- LSox5 regulates RhoB expression in the neural tube and promotes generation of the neural crest. | Perez-Alcala, S., et al. 2004. Development. 131: 4455-65. PMID: 15306568
- FOXD3 regulates anaplastic thyroid cancer progression. | Yin, H., et al. 2017. Oncotarget. 8: 33644-33651. PMID: 28430585
- FOXD3‑AS1/miR‑128‑3p/LIMK1 axis regulates cervical cancer progression. | Yang, X., et al. 2021. Oncol Rep. 45: PMID: 33760158
- FOXD3 and GAB2 as a pair of rivals antagonistically control hepatocellular carcinogenesis. | Liu, R., et al. 2022. FEBS J. 289: 4536-4548. PMID: 35178865
- Emerging Roles and Mechanisms of lncRNA FOXD3-AS1 in Human Diseases. | Yao, Q., et al. 2022. Front Oncol. 12: 848296. PMID: 35280790
- FOXD3-mediated transactivation of ALKBH5 promotes neuropathic pain via m6A-dependent stabilization of 5-HT3A mRNA in sensory neurons. | Huang, Z., et al. 2024. Proc Natl Acad Sci U S A. 121: e2312861121. PMID: 38285939
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FOXD3 Antibody (5G9B10) | sc-517206 | 50 µl ascites | $322.00 |