FOXD1 Antibody (2C10): sc-293238
- FOXD1 Antibody (2C10) is a mouse monoclonal IgG2b κ FOXD1 antibody provided at 100 µg/ml
- raised against a recombinant protein corresponding to amino acids 1-91 of FOXD1 of human origin
- recommended for detection of FOXD1 of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for FOXD1 Antibody (2C10). This work is in progress.
FOXD1 Antibody (2C10) is a mouse monoclonal IgG2b kappa light chain antibody that detects FOXD1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). FOXD1 (2C10) antibody is available as a non-conjugated anti-FOXD1 monoclonal isotype antibody. FOXD1, also known as brain factor 2 or BF-2, plays a crucial role in regulating inflammation and is essential for kidney and retinal development. Located primarily in the nucleus, FOXD1 is a transcription factor that influences the expression of genes involved in these processes. FOXD1′s proper function is vital, as FOXD1 regulates the activity of key signaling pathways, including NFAT and NFκB, which are critical for immune response and cellular growth. A deficiency in FOXD1 can lead to severe consequences, such as multiorgan systemic inflammation and renal abnormalities, highlighting FOXD1′s importance in maintaining homeostasis within the body. Furthermore, FOXD1′s interaction with other proteins, such as FOXD2, which modulates T cell activation, underscores FOXD1′s role in the immune system and potential implications in various diseases, including cancer and autoimmune disorders.
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FOXD1 Antibody (2C10) References:
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- A winged helix forkhead (FOXD2) tunes sensitivity to cAMP in T lymphocytes through regulation of cAMP-dependent protein kinase RIalpha. | Johansson, CC., et al. 2003. J Biol Chem. 278: 17573-9. PMID: 12621056
- Transcriptional activation of placental growth factor by the forkhead/winged helix transcription factor FoxD1. | Zhang, H., et al. 2003. Curr Biol. 13: 1625-9. PMID: 13678594
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- Foxd1 is required for proper formation of the optic chiasm. | Herrera, E., et al. 2004. Development. 131: 5727-39. PMID: 15509772
- Foxd1-dependent signals control cellularity in the renal capsule, a structure required for normal renal development. | Levinson, RS., et al. 2005. Development. 132: 529-39. PMID: 15634693
- Forkhead transcription factors in immunology. | Jonsson, H. and Peng, SL. 2005. Cell Mol Life Sci. 62: 397-409. PMID: 15719167
- Coordination of NF-kappaB and NFAT antagonism by the forkhead transcription factor Foxd1. | Lin, L. and Peng, SL. 2006. J Immunol. 176: 4793-803. PMID: 16585573
- The multisystemic functions of FOXD1 in development and disease. | Quintero-Ronderos, P. and Laissue, P. 2018. J Mol Med (Berl). 96: 725-739. PMID: 29959475
- FOXD1 facilitates pancreatic cancer cell proliferation, invasion, and metastasis by regulating GLUT1-mediated aerobic glycolysis. | Cai, K., et al. 2022. Cell Death Dis. 13: 765. PMID: 36057597
- FOXD1 expression-based prognostic model for uveal melanoma. | Luo, Y., et al. 2023. Heliyon. 9: e21333. PMID: 38027647
- Essential role of stromal mesenchyme in kidney morphogenesis revealed by targeted disruption of Winged Helix transcription factor BF-2. | Hatini, V., et al. 1996. Genes Dev. 10: 1467-78. PMID: 8666231
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FOXD1 Antibody (2C10) | sc-293238 | 100 µg/ml | $322.00 |