FOXC1 Antibody (4D11): sc-293455

FOXC1 Antibody (4D11) is a mouse monoclonal IgG2b kappa light chain antibody that detects FOXC1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-FOXC1 antibody (4D11) is available as a non-conjugated format. FOXC1 plays a crucial role as a forkhead transcription factor, influencing the development of various tissues, including the heart, blood vessels, and ocular structures. FOXC1 (4D11) antibody helps study the regulation of the Notch signaling pathway, which is essential for the prepatterning of somite domains during embryonic development. Mutations in FOXC1 can lead to significant developmental disorders, such as Axenfeld-Rieger malformations, which affect the anterior segment of the eye and increase the risk of glaucoma, including juvenile forms. FOXC1′s structure includes functional regions critical for nuclear localization and transcriptional activity, with specific domains rich in basic amino acids and highly conserved sequences among FOX proteins being vital for proper function. Anti-FOXC1 antibody (4D11) serves as an invaluable tool for researchers studying the intricate roles of FOXC1 in developmental biology and disease.

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FOXC1 Antibody (4D11) References:

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2. Haploinsufficiency of the transcription factors FOXC1 and FOXC2 results in aberrant ocular development.  |  Smith, RS., et al. 2000. Hum Mol Genet. 9: 1021-32. PMID: 10767326
3. The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis.  |  Kume, T., et al. 2001. Genes Dev. 15: 2470-82. PMID: 11562355
4. Screening for mutations of Axenfeld-Rieger syndrome caused by FOXC1 gene in Japanese patients.  |  Kawase, C., et al. 2001. J Glaucoma. 10: 477-82. PMID: 11740218
5. FOXC1 transcriptional regulation is mediated by N- and C-terminal activation domains and contains a phosphorylated transcriptional inhibitory domain.  |  Berry, FB., et al. 2002. J Biol Chem. 277: 10292-7. PMID: 11782474
6. FoxC1: Novel Regulator of Inflammation-Induced Metastasis in Hepatocellular Carcinoma.  |  Aravalli, RN. and Greten, TF. 2015. Gastroenterology. 149: 861-3. PMID: 26302490
7. The Diverse Consequences of FOXC1 Deregulation in Cancer.  |  Gilding, LN. and Somervaille, TCP. 2019. Cancers (Basel). 11: PMID: 30764547
8. Loss of FOXC1 contributes to the corneal epithelial fate switch and pathogenesis.  |  Li, M., et al. 2021. Signal Transduct Target Ther. 6: 5. PMID: 33414365
9. ELAVL1 is transcriptionally activated by FOXC1 and promotes ferroptosis in myocardial ischemia/reperfusion injury by regulating autophagy.  |  Chen, HY., et al. 2021. Mol Med. 27: 14. PMID: 33568052
10. A novel SIRT6 activator ameliorates neuroinflammation and ischemic brain injury via EZH2/FOXC1 axis.  |  He, T., et al. 2021. Acta Pharm Sin B. 11: 708-726. PMID: 33777677
11. Genotype-phenotype association of PITX2 and FOXC1 in Axenfeld-Rieger syndrome.  |  Zhou, L., et al. 2023. Exp Eye Res. 226: 109307. PMID: 36442680
12. FOXC1 regulates endothelial CD98 (LAT1/4F2hc) expression in retinal angiogenesis and blood-retina barrier formation.  |  Bhakuni, T., et al. 2024. Nat Commun. 15: 4097. PMID: 38755144