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Fosfomycin Calcium (CAS 26016-98-8)

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Alternate Names:
Calcium phosphomycin; Fosmicin
Application:
Fosfomycin Calcium is a bacterial wall synthesis inhibitor
CAS Number:
26016-98-8
Purity:
≥95%
Molecular Weight:
176.12
Molecular Formula:
C3H5CaO4P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Fosfomycin Calcium is a calcium salt form of fosfomycin and is leveraged in research studies focused on bacterial resistance mechanisms and the efficacy of antibacterial agents. In microbiology, it is used to investigate the inhibitory effects on bacterial wall synthesis, as it targets the initial stages of peptidoglycan production, a critical component of bacterial cell walls. This research is vital for understanding how bacteria develop resistance to certain mechanisms of action and for the subsequent design of novel compounds that can circumvent these resistances. By studying Fosfomycin Calcium, researchers can gain insights into the transport and uptake of phosphonic antibiotics by bacterial cells. Additionally, it serves as a benchmark in studies that examine the synergistic effects when used in combination with other compounds, which can be critical for enhancing the activity against resistant bacterial strains in various environmental conditions.


Fosfomycin Calcium (CAS 26016-98-8) References

  1. The effect of fosfomycin on neutrophil function.  |  Krause, R., et al. 2001. J Antimicrob Chemother. 47: 141-6. PMID: 11157896
  2. [Experimental studies on absorption, distribution and excretion of a new antibiotic, fosfomycin. II. Absorption of oral preparations of fosfomycin calcium salt in dogs (author's transl)].  |  Fujita, M., et al. 1975. Jpn J Antibiot. 28: 314-9. PMID: 1152285
  3. Fosfomycin therapy for multiresistant Pseudomonas aeruginosa in cystic fibrosis.  |  Mirakhur, A., et al. 2003. J Cyst Fibros. 2: 19-24. PMID: 15463841
  4. Pharmacokinetic comparison between fosfomycin and other phosphonic acid derivatives.  |  Bergan, T. 1990. Chemotherapy. 36 Suppl 1: 10-8. PMID: 2085981
  5. Quantitative 31P-NMR spectroscopy for the determination of fosfomycin and impurity A in pharmaceutical products of fosfomycin sodium or calcium.  |  Jiang, H., et al. 2015. Magn Reson Chem. 53: 454-9. PMID: 25855198
  6. Fosfomycin: Resurgence of an old companion.  |  Sastry, S. and Doi, Y. 2016. J Infect Chemother. 22: 273-80. PMID: 26923259
  7. Pharmacist-driven antimicrobial stewardship program in a long-term care facility by assessment of appropriateness.  |  Cantudo-Cuenca, MR., et al. 2022. Eur Geriatr Med. 13: 1357-1364. PMID: 36374428
  8. Protective effect of fosfomycin on the experimental nephrotoxicity induced by dibekacin.  |  Inouye, S., et al. 1982. J Pharmacobiodyn. 5: 659-69. PMID: 7153839
  9. MurA (MurZ), the enzyme that catalyzes the first committed step in peptidoglycan biosynthesis, is essential in Escherichia coli.  |  Brown, ED., et al. 1995. J Bacteriol. 177: 4194-7. PMID: 7608103
  10. Analysis of oral fosfomycin calcium (Fosmicin) side-effects after marketing.  |  Mayama, T., et al. 1993. Int J Clin Pharmacol Ther Toxicol. 31: 77-82. PMID: 8458680

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Fosfomycin Calcium, 5 g

sc-204760
5 g
$233.00

Fosfomycin Calcium, 25 g

sc-204760A
25 g
$490.00

Boa tarde. Essa fosfomicina é comercializada em pó? Qual é a forma de preparo? Obrigada

Asked by: Juliana Nardi Bortolança
Thank you for your question. This is provided in a powder form.
Answered by: Technical Support
Date published: 2019-09-11
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Rated 5 out of 5 by from Great price, and qualityGreat quality product, works well, very quick response time
Date published: 2024-09-13
Rated 5 out of 5 by from Réponse très rapideje suis contente du service ,parfait! merci beaucoup
Date published: 2021-11-30
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Fosfomycin Calcium is rated 5.0 out of 5 by 2.
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