Molecular structure of Foscarnet sodium, CAS Number: 63585-09-1
Foscarnet sodium (CAS 63585-09-1)
Alternate Names:
Foscavir; Trisodium phosphonoformate
Application:
Foscarnet sodium is a structural mimic of the anion pyrophosphate that selectively regulates DNA polymerase
CAS Number:
63585-09-1
Purity:
≥97%
Molecular Weight:
191.95
Molecular Formula:
CO5P•3Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Foscarnet sodium is a structural mimic of the anion pyrophosphate the selectively regulates DNA polymerase. Foscarnet sodium functions as a potent inhibitor of viral DNA polymerase, effectively binding to its active site and obstructing the enzyme′s capacity to catalyze phosphodiester bond formation between the 3′-OH and 5′-P ends of DNA strands. By doing so, it effectively halts the replication of viral DNA, leading to the inhibition of viral replication.
Foscarnet sodium (CAS 63585-09-1) References
- Dosing guidelines for foscarnet and trimetrexate. | Wooten, JM., et al. 1995. Formulary. 30: 349-52. PMID: 10144874
- Autoclave and long-term sterility of foscarnet sodium admixtures. | Stolk, LM., et al. 1995. Am J Health Syst Pharm. 52: 103. PMID: 12879531
- Cytomegalovirus infections in pediatric liver transplantation. | King, SM., et al. 1990. Am J Dis Child. 144: 1307-10. PMID: 2173888
- Antiviral effects of phosphonoformate (PFA, foscarnet sodium). | Oberg, B. 1989. Pharmacol Ther. 40: 213-85. PMID: 2543994
- A comparison study on the clinical effects of foscarnet sodium injection and interferon on human immunodeficiency virus-infected patients complicated with herpes zoster. | Yuan-Qu, Y., et al. 2015. Pak J Med Sci. 31: 309-13. PMID: 26101481
- Foscarnet calcium microcrystals as the intravitreal drug depot. | Sun, Y., et al. 2017. Chem Commun (Camb). 53: 5139-5142. PMID: 28435952
- Changes and Treatment Prognosis of Aqueous Humor Cytokine Concentrations of Patients with Acquired Immune Deficiency Syndrome Complicated by Cytomegalovirus Retinitis. | Kong, W., et al. 2022. J Ocul Pharmacol Ther. 38: 695-702. PMID: 36378859
- The Peculiarity of Infection and Immunity Correlated with Guillain-Barré Syndrome in the HIV-Infected Population. | Wang, Y., et al. 2023. J Clin Med. 12: PMID: 36769555
- Antiviral effects of phosphonoformate (PFA, foscarnet sodium). | Oberg, B. 1982. Pharmacol Ther. 19: 387-415. PMID: 6201932
- Therapeutic effects of foscarnet sodium and acyclovir on cutaneous infections due to herpes simplex virus type 1 in guinea pigs. | Alenius, S., et al. 1982. J Infect Dis. 145: 569-73. PMID: 6279738
- Stability of foscarnet sodium in 0.9% sodium chloride injection. | Woods, K., et al. 1994. Am J Hosp Pharm. 51: 88-90. PMID: 8135266
- Stability of foscarnet sodium in 5% dextrose and 0.9% sodium chloride injections. | Mathew, M., et al. 1994. J Clin Pharm Ther. 19: 35-6. PMID: 8188788
- Combination ganciclovir and foscarnet in the treatment of clinically resistant cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome. | Kuppermann, BD., et al. 1993. Arch Ophthalmol. 111: 1359-66. PMID: 8216016
Inhibitor of:
Adenovirus hexon protein, Adenovirus-5 hexon, APOBEC3A, CMV, CMV gB, CMV gH, CMV pp28, CMV pp72, CMV pp86, DNA pol β, DNA pol δ 2, DNA pol γ2, HHV-8, HHV-8 B, HHV-8 K14, HSV-1, HSV-1 gB, HSV-1 gC, HSV-1 gG, HSV-1 ICP0, HSV-1 ICP4, HSV-1 UL42, HSV-2, HSV-2 gD, HSV-2 gE Envelope Protein, HSV-2 gG, HSV-2 gG Envelope Protein, HSV-2 ICP8 Major DNA binding protein, IAP, KSHV ORF 62, LINE-1, NPT2, PAPSS2, PAPST1, RNA pol α, RNA Polymerase, Varicella Zoster Virus gpI, Varicella Zoster Virus gpIII, Varicella Zoster Virus gpIV, Varicella Zoster Virus IE62, Varicella Zoster Virus IV, Varicella-Zoster Virus (VZV), VP16, VZV gE, and VZV thymidine kinase.Activator of:
Adenovirus-5 hexon, HHV-6 p37 early antigen, HSV-1 ICP8, HSV-1 Thymidine Kinase, HSV-1 VP22, HSV-2 gB, HSV-2 VP22, and Rubella Virus structural glycoprotein.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Foscarnet sodium, 1 g | sc-205330 | 1 g | $186.00 | |||
Foscarnet sodium, 5 g | sc-205330A | 5 g | $663.00 |