Fos B Antibody (C-11): sc-8013
- Fos B Antibody (C-11) is a mouse monoclonal IgM κ, cited in 10 publications, provided at 200 µg/ml
- raised against amino acids 75-150 mapping at the N-terminus of Fos B of human origin
- recommended for detection of Fos B of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- available conjugated to agarose for IP
- TransCruz reagent for Gel Supershift and ChIP applications (sc-8013 X, 200 µg/0.1 ml)
- See Fos B (F-7): sc-398595 for Fos B antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Fos B Antibody (C-11). This work is in progress.
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FosB Antibody (C-11) is a mouse monoclonal IgM kappa light chain antibody raised against amino acids 75-150 at the N-terminus of human FosB, a nuclear phosphoprotein crucial for transcriptional regulation. Anti-FosB antibody (C-11) recognizes an epitope within this N-terminal region and demonstrates broad species cross-reactivity, detecting FosB in mouse, rat, and human samples through Western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry on paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA) applications. As a member of the Fos protein family, FosB responds rapidly to various cellular stimuli and shares approximately 70% sequence homology with c-Fos. However, FosB exhibits distinct functional characteristics from c-Fos. While c-Fos can form both homo- and heterodimers with c-Jun proteins to bind DNA TPA response elements (TREs), FosB primarily operates through heterodimer formation with c-Jun and JunB proteins to activate transcription. The regulation of FosB activity involves sophisticated post-translational modifications, particularly phosphorylation, which proves essential for FosB′s stability and transcriptional activity. Also known as Transcription factor AP-1 and Fos-related antigen 2 (Fra-2), FosB plays vital roles in cell differentiation, proliferation, and stress responses. Through these diverse cellular functions, FosB (C-11) antibody provides researchers with a valuable tool for investigating transcriptional regulation and cellular signaling pathways across multiple species.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fos B Antibody (C-11) | sc-8013 | 200 µg/ml | $316.00 | |||
Fos B Antibody (C-11) AC | sc-8013 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Fos B Antibody (C-11) X | sc-8013 X | 200 µg/0.1 ml | $316.00 |