Forssman Antigen Antibody (M1/87): sc-23939

Forssman Antigen Antibody (M1/87) is a rat monoclonal IgM antibody that detects Forssman Antigen protein of mouse, rat, human, and ovine origin by flow cytometry (FCM). Anti-Forssman Antigen antibody (M1/87) is available in both non-conjugated and various conjugated forms, including phycoerythrin (PE) and fluorescein isothiocyanate (FITC). Forssman Antigen is a glycolipid heterophil protein that plays a significant role in cellular interactions and immune responses, being expressed in the tissues of many species. Notably, Forssman Antigen presence has been linked to several human cancers, such as gastric, colon, and lung cancers, highlighting its potential as a biomarker for disease progression. In mice, Forssman Antigen serves as a developmental and differentiation-associated antigen, with expression in macrophages being modulated by cytokines, which underscores its importance in immune regulation and response. Forssman Antigen was named after the Swedish pathologist John F. Forssman and was later identified as the GalNAc(1-3)/GalNAc(1-R) disaccharide group, which is crucial for biological activity and interactions with other cellular components.

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Forssman Antigen Antibody (M1/87) References:

1. Forssman glycolipid, an antigenic marker for a major subpopulation of macrophages from murine spleen and peripheral lymph nodes.  |  Bethke, U., et al. 1987. J Immunol. 138: 4329-35. PMID: 3495590
2. Monoclonal antibodies as probes for differentiation and tumor-associated antigens: a Forssman specificity on teratocarcinoma stem cells.  |  Stern, PL., et al. 1978. Cell. 14: 775-83. PMID: 567532
3. Markers of mouse macrophage development detected by monoclonal antibodies.  |  Leenen, PJ., et al. 1994. J Immunol Methods. 174: 5-19. PMID: 8083537
4. Monoclonal xenogeneic antibodies to murine cell surface antigens: identification of novel leukocyte differentiation antigens.  |  Springer, T., et al. 1978. Eur J Immunol. 8: 539-51. PMID: 81133
5. Surface expression of Forssman glycosphingolipid antigen on murine bone marrow-derived macrophages is subject to both temporal and population-specific regulation and is modulated by IL-4 and IL-6.  |  Monner, DA. and Mühlradt, PF. 1993. Immunobiology. 188: 82-98. PMID: 8406561

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Forssman Antigen Antibody (M1/87) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Forssman Antigen Antibody (M1/87) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Forssman Antigen Antibody (M1/87) Specifications

Alternate Product Name: Forssman Antigen

Product Clone Name: M1/87

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM

Amino Acids:

Epitope Target: Forssman Antigen

Epitope Species: mouse

Product Reactivity/Detection: Forssman Antigen

Species Reactivity/Detection: mouse, rat, human, ovine

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: FCM

Vialing Information: Each vial contains 200 µg IgM in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Forssman Antigen Antibody (M1/87): FITC: Fluoroscein, L: Azide-Free, PE: Phycoerythrin