Folitixorin (Mixture of Diastereomers) (CAS 3432-99-3)
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Folitixorin (Mixture of Diastereomers) is a vital molecule present in cells, serving as an essential cofactor for various biological processes. The enzyme methylenetetrahydrofolate reductase facilitates the synthesis of the folate form of Folitixorin. This conversion occurs by utilizing N5,N10-methenyltetrahydrofolate as a substrate, leading to the production of Folitixorin. Methotrexate can hinder the activity of methylenetetrahydrofolate reductase, inhibiting the formation of Folitixorin (Mixture of Diastereomers) and subsequently decreasing the body′s folate supply. Structural analysis of Folitixorin (Mixture of Diastereomers) has been carried out through titration calorimetry and x-ray crystallography techniques.
Folitixorin (Mixture of Diastereomers) (CAS 3432-99-3) References
- Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based Inhibitor. | Gustafsson, R., et al. 2017. Cancer Res. 77: 937-948. PMID: 27899380
- Arginine methylation of MTHFD1 by PRMT5 enhances anoikis resistance and cancer metastasis. | Meng, Q., et al. 2022. Oncogene. 41: 3912-3924. PMID: 35798877
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Folitixorin (Mixture of Diastereomers), 5 mg | sc-470660 | 5 mg | $504.00 | |||
Folitixorin (Mixture of Diastereomers), 50 mg | sc-470660A | 50 mg | $3050.00 |