Molecular structure of Folinic Acid, CAS Number: 58-05-9
Folinic Acid (CAS 58-05-9)
Alternate Names:
Leucovorin
CAS Number:
58-05-9
Molecular Weight:
473.44
Molecular Formula:
C20H23N7O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Folinic acid, also known as leucovorin, is a form of folate that can be used in biochemical assays as a cofactor in various enzymatic reactions. In research applications, it is often utilized in studies examining the folate cycle and its role in cellular metabolism. Folinic acid is also used in analytical chemistry to create calibration curves for the quantification of folate levels in nutritional studies. It serves as a reference compound in the development of assays to measure folate in biological samples. In molecular biology, folinic acid may be used to modulate the synthesis of nucleic acids.
Folinic Acid (CAS 58-05-9) References
- Folinic acid supplementation in higher doses is associated with graft rejection in pediatric hematopoietic stem cell transplantation. | Lindqvist, H., et al. 2013. Biol Blood Marrow Transplant. 19: 325-8. PMID: 23200704
- Folinic acid treatment for schizophrenia associated with folate receptor autoantibodies. | Ramaekers, VT., et al. 2014. Mol Genet Metab. 113: 307-14. PMID: 25456743
- Does folinic acid ameliorates retinoic acid induced teratogenicity in chick embryo? | Haque, A. and Khan, MY. 2016. J Pak Med Assoc. 66: 302-5. PMID: 26968281
- Folinic Acid Increases Protein Arginine Methylation in Human Endothelial Cells. | Esse, R., et al. 2018. Nutrients. 10: PMID: 29587354
- Effects of leucovorin (folinic acid) in the methotrexate-treated rat brain. | Ogushi, N., et al. 2018. J Vet Med Sci. 80: 760-765. PMID: 29607891
- Topical folinic acid enhances wound healing in rat model. | Duman, N., et al. 2018. Adv Med Sci. 63: 347-352. PMID: 30092503
- Nano Codelivery of Oxaliplatin and Folinic Acid Achieves Synergistic Chemo-Immunotherapy with 5-Fluorouracil for Colorectal Cancer and Liver Metastasis. | Guo, J., et al. 2020. ACS Nano. 14: 5075-5089. PMID: 32283007
- Folinic acid over rescue of high dose methotrexate: How problematic citations conserve discredited concepts. | Cohen, IJ. 2021. Med Hypotheses. 146: 110467. PMID: 33401105
- Effect of folinic acid on serum homocysteine, TNFα, IL-10, and HMGB1 gene expression in head injury model. | Tommy, T., et al. 2021. Ann Med Surg (Lond). 65: 102273. PMID: 33996045
- Reduced dose folinic acid rescue after rapid high-dose methotrexate clearance is not associated with increased toxicity in a pediatric cohort. | Niinimäki, R., et al. 2022. Support Care Cancer. 30: 127-133. PMID: 34235555
- Folinic acid rescue during methotrexate treatment for low-risk gestational trophoblastic neoplasia - How much is just right? | Poli, JG., et al. 2021. Gynecol Oncol. 162: 638-644. PMID: 34266689
- Effects of Folinic Acid Administration on Lower Limb Ischemia/Reperfusion Injury in Rats. | Cearra, I., et al. 2021. Antioxidants (Basel). 10: PMID: 34942991
- Folinic Acid Potentiates the Liver Regeneration Process after Selective Portal Vein Ligation in Rats. | Gutiérrez Sáenz de Santa María, J., et al. 2022. Cancers (Basel). 14: PMID: 35053534
- Edible folic acid and medicinal folinic acid produce cardioprotective effects in late-stage triple-transgenic Alzheimer's disease model mice by suppressing cardiac hypertrophy and fibrosis. | Huang, CY., et al. 2022. Environ Toxicol. 37: 1740-1749. PMID: 35286012
- Pharmacologic modulation of 5-fluorouracil by folinic acid and pyridoxine for treatment of patients with advanced breast carcinoma. | Machover, D., et al. 2022. Sci Rep. 12: 9079. PMID: 35641554
Inhibitor of:
LOC400958, and SLC38A8.Activator of:
AICAR transformylase, ALDH1L1, C8orf79_6430573F11Rik, CTPS2, CTU1, DDC, DPRP1, DTYMK, eIF1AX, FPGS, GlyT2, GMPS, HISPPD2A, KAT II, KIAA1429, METTL8, MFT, MGC50559_4833442J19Rik, MTHFS, PRPS1L1, RNMT, Thioguanine, TYW1, UMPS, and WDSUB1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Folinic Acid, 5 mg | sc-337846A | 5 mg | $110.00 | |||
Folinic Acid, 25 mg | sc-337846B | 25 mg | $291.00 | |||
Folinic Acid, 100 mg | sc-337846 | 100 mg | $592.00 |