FMR1 Antibody (4G9): sc-293156

FMR1 Antibody (4G9) is a mouse monoclonal IgG1 antibody that detects FMR1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-FMR1 antibody (4G9) is available as the non-conjugated form. FMR1 protein, also known as fragile X mental retardation protein (FMRP), plays a crucial role in regulating synaptic plasticity and is essential for normal cognitive function. FMR1 is primarily located in the cytoplasm, where FMR1 associates with polyribosomes to facilitate the translation of specific mRNAs, thereby influencing protein synthesis in response to neuronal activity. This localization enables FMR1 to modulate the translation of proteins involved in synaptic development and function, which is particularly important for learning and memory processes. In fragile X syndrome, FMR1 gene undergoes transcriptional silencing due to the expansion of a CGG repeat in its 5′ untranslated region, leading to FMRP deficiency. FMRP absence disrupts normal synaptic function and contributes to cognitive impairments associated with the disorder. Additionally, FMR1 interacts with other proteins such as FXR1 and FXR2, which are also implicated in fragile X syndrome, forming heterodimers that may further influence mRNA transport and translation. FMR1′s ability to shuttle between the nucleus and cytoplasm underscores its importance in nucleocytoplasmic transport of mRNAs, highlighting its multifaceted role in cellular function and relevance in neurodevelopmental disorders.

The preferred FMR1 antibody is FMR1 Antibody (D-6): sc-518105.