Fmoc-Tyr(PO3H2)-OH (CAS 147762-53-6)
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Fmoc-Tyr(PO3H2)-OH is an Fmoc protected tyrosine derivative that is potentially useful for proteomics studies and solid phase peptide synthesis techniques. Tyrosine is a very important amino acid - one of the few amino acids which is phosphorylated to vary the physical properties of the peptides, and is a precursor for the formation of iodinated thyroid hormones. The Fmoc group is typically removed with a base such as pyridine - an orthogonal de-protection strategy to the acid labilie Boc group. Fmoc-Tyr(PO3H2)-OH is a phosphopeptide employed in biochemistry and molecular biology research. It is a modified version of tyrosine, a occurring amino acid in proteins, achieved through the addition of a fluorenylmethoxycarbonyl (Fmoc) group and a phosphate group.
Fmoc-Tyr(PO3H2)-OH (CAS 147762-53-6) References
- Design and synthesis of Fmoc-Thr[PO(OH)(OPOM)] for the preparation of peptide prodrugs containing phosphothreonine in fully protected form. | Qian, WJ., et al. 2014. Chem Biodivers. 11: 784-91. PMID: 24827688
- Intramolecular pyrophosphate formation during N alpha-9-fluorenylmethyloxycarbonyl (Fmoc) solid-phase synthesis of peptides containing adjacent phosphotyrosine residues. | Ottinger, EA., et al. 1996. Pept Res. 9: 223-8. PMID: 9000247
- Phosphotyrosine 1173 mediates binding of the protein-tyrosine phosphatase SHP-1 to the epidermal growth factor receptor and attenuation of receptor signaling. | Keilhack, H., et al. 1998. J Biol Chem. 273: 24839-46. PMID: 9733788
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fmoc-Tyr(PO3H2)-OH, 1 g | sc-228225 | 1 g | $99.00 |