Date published: 2025-11-1

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Fmoc-Trp(Boc)-OH (CAS 143824-78-6)

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CAS Number:
143824-78-6
Purity:
≥99%
Molecular Weight:
526.58
Molecular Formula:
C31H30N2O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Fmoc-Trp(Boc)-OH is a highly favored amino acid derivative employed in peptide synthesis. With extensive applications in biochemistry, and biophysics, it serves as a vital tool for modifying peptides and proteins. From small peptides to large proteins, Fmoc-Trp(Boc)-OH finds widespread use in scientific investigations, enabling researchers to explore the intricacies of molecular structure and function. Its versatile nature facilitates modifications, empowering researchers to tailor peptides and proteins according to their needs. The Fmoc-Trp(Boc)-OH molecule combines the Fmoc and tert-butoxycarbonyl (Boc) groups with an L-tryptophan molecule. These protecting groups serve a role by preventing the L-tryptophan from reacting with other molecules prematurely. This enables precise control over modifications during peptide synthesis, ensuring accurate study and analysis of the modified peptides and proteins.


Fmoc-Trp(Boc)-OH (CAS 143824-78-6) References

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  2. Click-Free Synthesis of a Multivalent Tricyclic Peptide as a Molecular Transporter.  |  Kumar, S., et al. 2020. Pharmaceutics. 12: PMID: 32899170
  3. Development of Ligand-Drug Conjugates Targeting Melanoma through the Overexpressed Melanocortin 1 Receptor.  |  Zhou, Y., et al. 2020. ACS Pharmacol Transl Sci. 3: 921-930. PMID: 33073191
  4. Atropselective Hydrolysis of Chiral Binol-Phosphate Esters Catalyzed by the Phosphotriesterase from Sphingobium sp. TCM1.  |  Xiang, DF., et al. 2020. Biochemistry. 59: 4463-4469. PMID: 33167613
  5. Cyclic Peptides as Protein Kinase Inhibitors: Structure-Activity Relationship and Molecular Modeling.  |  Sanner, MF., et al. 2021. J Chem Inf Model. 61: 3015-3026. PMID: 34000187
  6. Optimized Fmoc-Removal Strategy to Suppress the Traceless and Conventional Diketopiperazine Formation in Solid-Phase Peptide Synthesis.  |  Yang, Y. and Hansen, L. 2022. ACS Omega. 7: 12015-12020. PMID: 35449974
  7. Dipropylamine for 9-Fluorenylmethyloxycarbonyl (Fmoc) Deprotection with Reduced Aspartimide Formation in Solid-Phase Peptide Synthesis.  |  Personne, H., et al. 2023. ACS Omega. 8: 5050-5056. PMID: 36777595
  8. Synthesis of Polysubstituted Pyridines and Pyrazines via Truce-Smiles Rearrangement of Amino Acid-Based 4-Nitrobenzenesulfonamides.  |  Tkadlecová, M., et al. 2023. J Org Chem. 88: 3228-3237. PMID: 36797215
  9. Effect of Newly Synthesized Structures of Peptides on the Stability of the Monolayers Formed.  |  Golonka, I., et al. 2023. Int J Mol Sci. 24: PMID: 36901749
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  11. Total Synthesis and Structure Assignment of the Relacidine Lipopeptide Antibiotics and Preparation of Analogues with Enhanced Stability.  |  Al Ayed, K., et al. 2023. ACS Infect Dis. 9: 739-748. PMID: 37000899
  12. Tripeptides conjugated with thiosemicarbazones: new inhibitors of tyrosinase for cosmeceutical use.  |  Ledwoń, P., et al. 2023. J Enzyme Inhib Med Chem. 38: 2193676. PMID: 37146256
  13. Oxime and thiazolidine chemoselective ligation reactions: a green method for cotton functionalization.  |  Albini, F., et al. 2023. Cellulose (Lond). 30: 5573-5587. PMID: 37304190

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Fmoc-Trp(Boc)-OH, 5 g

sc-228222
5 g
$56.00