Date published: 2025-10-15

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Fmoc-Pro-OH (CAS 71989-31-6)

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Alternate Names:
Fmoc-L-proline
CAS Number:
71989-31-6
Molecular Weight:
337.37
Molecular Formula:
C20H19NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Fmoc-Pro-OH, also known as Fmoc-P-OH, is a synthetic amino acid derived from proline. It has gained widespread popularity in the fields of biochemistry and medicinal chemistry due to its versatile properties. Its applications have seen steady growth over time. Researchers have found various uses for Fmoc-P-OH in scientific research. Notably, it has been instrumental in synthesizing peptides and proteins and in the development of new agents. Additionally, Fmoc-P-OH has been extensively employed in both in vivo and in vitro studies, with a focus on enzyme function, protein structure, and drug design investigations. A notable mechanism of action for Fmoc-P-OH involves acting as a competitive inhibitor of enzymes, particularly proteases. By binding to the active sites of these enzymes, it prevents them from interacting with their natural substrates, effectively inhibiting their activity.


Fmoc-Pro-OH (CAS 71989-31-6) References

  1. Optimized Fmoc-Removal Strategy to Suppress the Traceless and Conventional Diketopiperazine Formation in Solid-Phase Peptide Synthesis.  |  Yang, Y. and Hansen, L. 2022. ACS Omega. 7: 12015-12020. PMID: 35449974
  2. Neurotensin analogs by fluoroglycosylation at Nω-carbamoylated arginines for PET imaging of NTS1-positive tumors.  |  Schindler, L., et al. 2022. Sci Rep. 12: 15028. PMID: 36056076
  3. Novel inhibitors and activity-based probes targeting serine proteases.  |  Ferguson, TEG., et al. 2022. Front Chem. 10: 1006618. PMID: 36247662
  4. Mechanistic Study of Diketopiperazine Formation during Solid-Phase Peptide Synthesis of Tirzepatide.  |  Wang, J., et al. 2022. ACS Omega. 7: 46809-46824. PMID: 36570276
  5. The Anti-Tubercular Aminolipopeptide Trichoderin A Displays Selective Toxicity against Human Pancreatic Ductal Adenocarcinoma Cells Cultured under Glucose Starvation.  |  Kasim, JK., et al. 2023. Pharmaceutics. 15: PMID: 36678914
  6. Dipropylamine for 9-Fluorenylmethyloxycarbonyl (Fmoc) Deprotection with Reduced Aspartimide Formation in Solid-Phase Peptide Synthesis.  |  Personne, H., et al. 2023. ACS Omega. 8: 5050-5056. PMID: 36777595
  7. Synthesis of Polysubstituted Pyridines and Pyrazines via Truce-Smiles Rearrangement of Amino Acid-Based 4-Nitrobenzenesulfonamides.  |  Tkadlecová, M., et al. 2023. J Org Chem. 88: 3228-3237. PMID: 36797215
  8. Design, Synthesis, and Biological Evaluation of the First Radio-Metalated Neurotensin Analogue Targeting Neurotensin Receptor 2.  |  Bodin, S., et al. 2023. ACS Omega. 8: 6994-7004. PMID: 36844603
  9. Coating Methods of Carbon Nonwovens with Cross-Linked Hyaluronic Acid and Its Conjugates with BMP Fragments.  |  Magdziarz, S., et al. 2023. Polymers (Basel). 15: PMID: 36987331
  10. Improved LC-MS identification of short homologous peptides using sequence-specific retention time predictors.  |  Hollebrands, B., et al. 2023. Anal Bioanal Chem. 415: 2715-2726. PMID: 37000211
  11. Food-inspired peptides from spinach Rubisco endowed with antioxidant, antinociceptive and anti-inflammatory properties.  |  Marinaccio, L., et al. 2023. Food Chem X. 18: 100640. PMID: 37008720
  12. LWJ-M30, a conjugate of DM1 and B6, for the targeted therapy of colorectal cancer with improved therapeutic effects.  |  Zhang, QY., et al. 2023. RSC Adv. 13: 10840-10846. PMID: 37033427
  13. Dipropyleneglycol Dimethylether, New Green Solvent for Solid-Phase Peptide Synthesis: Further Challenges to Improve Sustainability in the Development of Therapeutic Peptides.  |  Vivenzio, G., et al. 2023. Pharmaceutics. 15: PMID: 37376220

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Fmoc-Pro-OH, 5 g

sc-250016
5 g
$31.00