Fmoc-piperazine hydrochloride (CAS 215190-22-0)

Fmoc-piperazine hydrochloride is a valuable organic compound extensively employed in the synthesis of pharmaceuticals and diverse compounds. It exists as a white, crystalline powder with a melting point of approximately 97°C and a molecular weight of 208.7 g/mol. Derived from piperazine, a cyclic compound comprising two nitrogen atoms and three carbon atoms, Fmoc-piperazine hydrochloride serves as a common reagent in organic synthesis and finds broad applications in the pharmaceutical, agricultural, and specialty chemical industries. Fmoc-piperazine hydrochloride exhibits strong nucleophilicity, allowing it to react with electrophiles like carbonyl compounds, forming covalent bonds. It displays reactivity towards a wide range of electrophiles, including ketones, aldehydes, carboxylic acids, and esters. Furthermore, it can engage with other nucleophiles like amines and amides, facilitating the formation of covalent bonds. Thus, as nucleophilic reagent, Fmoc-piperazine hydrochloride plays a pivotal role in the synthesis of diverse compounds, such as various pharmaceuticals, including antifungal agents, anti-inflammatory drugs, and anti-cancer drugs. Additionally, it is instrumental in peptide synthesis, which is for the development of novel drugs. Fmoc-piperazine hydrochloride also contributes to the synthesis of other compounds such as macrocycles, polymers, and organic compounds. Moreover, it plays a significant role in synthesizing peptide aldehydes, which are vital in drug development.