Date published: 2026-2-14

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Fmoc-Photo-Linker (CAS 162827-98-7)

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Alternate Names:
Fmoc-Photo-Linker is also known as Fmoc-Photolabile Linker.
Application:
Fmoc-Photo-Linker is an Fmoc-amino photolabile-linker used in the solid-phase synthesis of peptide amides.
CAS Number:
162827-98-7
Molecular Weight:
520.56
Molecular Formula:
C28H28N2O8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Fmoc-Photo-Linker is an Fmoc-amino photo-linker for the synthesis of peptide amides. Fmoc-Photo-Linker is usually cleaved under acidic conditions or using two-step procedures. Photocleavage of Fmoc-Photo-Linker proceeds under neutral conditions with UV light. Photocleavage of Fmoc-Photo-Linker can be performed using flow chemistry. Fmoc-Photo-Linker is used in standard peptide chemistry reaction conditions, enabling the use of many various amino acid protecting groups. Fmoc-Photo-Linker is also known as Fmoc-Photolabile Linker, 4-[4-[1-(FMOC)ETHYL]-2-METHOXY-5-NITROPHENOXY]BUTANOIC ACID, and 4-{4-[1-(9-Fluorenylmethyloxycarbonylamino)ethyl]-2-methoxy-5-nitrophenoxy}butanoic acid.


Fmoc-Photo-Linker (CAS 162827-98-7) References

  1. Screening of LPS-specific peptides from a phage display library using epoxy beads.  |  Kim, YG., et al. 2005. Biochem Biophys Res Commun. 329: 312-7. PMID: 15721308
  2. High-throughput screening of glycan-binding proteins using miniature pig kidney N-glycan-immobilized beads.  |  Kim, YG., et al. 2008. Chem Biol. 15: 215-23. PMID: 18355721
  3. Surface modification by 2-methacryloyloxyethyl phosphorylcholine coupled to a photolabile linker for cell micropatterning.  |  Jang, K., et al. 2009. Biomaterials. 30: 1413-20. PMID: 19081624
  4. Development of high-throughput phosphorylation profiling method for identification of Ser/Thr kinase specificity.  |  Kim, EM., et al. 2011. J Pept Sci. 17: 392-7. PMID: 21480437
  5. Design and characterization of a synthetically accessible, photodegradable hydrogel for user-directed formation of neural networks.  |  McKinnon, DD., et al. 2014. Biomacromolecules. 15: 2808-16. PMID: 24932668
  6. Effects of the properties of short peptides conjugated with cell-penetrating peptides on their internalization into cells.  |  Matsumoto, R., et al. 2015. Sci Rep. 5: 12884. PMID: 26256261
  7. A Family of Photolabile Nitroveratryl-Based Surfactants That Self-Assemble into Photodegradable Supramolecular Structures.  |  Hwang, L., et al. 2016. Langmuir. 32: 3963-9. PMID: 27046005
  8. Effective modification of cell death-inducing intracellular peptides by means of a photo-cleavable peptide array-based screening system.  |  Kozaki, I., et al. 2017. J Biosci Bioeng. 124: 209-214. PMID: 28431917
  9. Pep-MS assay: Protease hydrolysis assay system using photo-cleavable peptide array and mass spectrometer.  |  Kurimoto, M., et al. 2019. J Biosci Bioeng. 128: 156-161. PMID: 30862433
  10. Disulfide linked hetero dimeric peptide arrays for screening functional peptides inside cells.  |  Kozaki, I., et al. 2020. J Biosci Bioeng. 129: 613-618. PMID: 31839388
  11. Antidepressive effect of an inward rectifier K+ channel blocker peptide, tertiapin-RQ.  |  Okada, M., et al. 2020. PLoS One. 15: e0233815. PMID: 33186384
  12. Design, Synthesis, and Biological Evaluation of Light-Activated Antibiotics.  |  Shchelik, IS., et al. 2021. ACS Infect Dis. 7: 681-692. PMID: 33656844
  13. Selective concentration of antimicrobial peptides to heat-treated porous silica gel using adsorption/desorption.  |  Hagawa, H., et al. 2022. J Biosci Bioeng. 133: 161-167. PMID: 34848124
  14. Glycosaminoglycan Mimetic Precision Glycomacromolecules with Sequence-Defined Sulfation and Rigidity Patterns.  |  Hoffmann, M., et al. 2022. Biomacromolecules. 23: 4004-4014. PMID: 35959886
  15. A photocaged orexin-B for spatiotemporally precise control of orexin signaling.  |  Duffet, L., et al. 2022. Cell Chem Biol. 29: 1729-1738.e8. PMID: 36481097

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Fmoc-Photo-Linker, 100 mg

sc-294977
100 mg
$269.00

Fmoc-Photo-Linker, 1 g

sc-294977A
1 g
$662.00

Fmoc-Photo-Linker, 5 g

sc-294977B
5 g
$1641.00