Date published: 2025-11-1

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Fmoc-Phe-OH (CAS 35661-40-6)

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Alternate Names:
N-9-Fmoc-L-phenylglycine; N-(9-Fluorenylmethoxycarbonyl)-L-phenylalanine; Fmoc-L-phenylalanine
CAS Number:
35661-40-6
Molecular Weight:
387.43
Molecular Formula:
C24H21NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Fmoc-Phe-OH is a derivative of L-Phenylalanine with inherent antimicrobial qualities. This natural substance plays a role in the preparation deltorphin derivatives. It is an inhibitor of the IGF-I and IGF-Binding Protein-5 complex. Fmoc-Phe-OH is particularly utilized in the solid-phase peptide synthesis method for preparing peptide sequences.


Fmoc-Phe-OH (CAS 35661-40-6) References

  1. Peptide recognition via hierarchical imprinting.  |  Titirici, MM. and Sellergren, B. 2004. Anal Bioanal Chem. 378: 1913-21. PMID: 14758460
  2. Solid-phase peptide synthesis using nanoparticulate amino acids in water.  |  Hojo, K., et al. 2007. J Pept Sci. 13: 493-7. PMID: 17554805
  3. Effect of C-terminal modification on the self-assembly and hydrogelation of fluorinated Fmoc-Phe derivatives.  |  Ryan, DM., et al. 2011. Langmuir. 27: 4029-39. PMID: 21401045
  4. Novel nanoparticles generated by polymeric amphiphiles with pi-pi conjugated small molecules for anti-tumor drug delivery.  |  Deng, X., et al. 2013. J Biomed Nanotechnol. 9: 1336-44. PMID: 23926799
  5. Synthesis of Macromolecules Containing Phenylalanine and Aliphatic Building Blocks.  |  Chan-Seng, D., et al. 2018. Macromol Rapid Commun. 39: e1700764. PMID: 29409141
  6. Technetium-99 m-PEGylated dendrimer-G2-(Dabcyle-Lys6,Phe7)-pHBSP: A novel Nano-Radiotracer for molecular and early detecting of cardiac ischemic region.  |  Mohtavinejad, N., et al. 2020. Bioorg Chem. 98: 103731. PMID: 32171100
  7. Single Amino-Acid Based Self-Assembled Biomaterials with Potent Antimicrobial Activity.  |  Misra, S., et al. 2021. Chemistry. 27: 16744-16753. PMID: 34468048
  8. Synthesis of gem-diamino derivatives on solid support  |  Sonia Cantel, Damien Boeglin, Marc Rolland, Jean Martinez, Jean-Alain Fehrentz. 2003. Tetrahedron Letters. 44: 4797-4799.
  9. Development of a Method for the Solid-Phase Peptide Synthesis in Water  |  Keiko Hojo, Hideki Ichikawa, Yoshinobu Fukumori & Koichi Kawasaki. 2008. International Journal of Peptide Research and Therapeutics. 14: 373–380.
  10. Amino acid based smart hydrogel: formation, characterization and fluorescence properties of silver nanoclusters within the hydrogel matrix  |  Subhasish Roya and Arindam Banerjee*a. 2011. Soft Matter,. 7: 5300-5308.
  11. Functionalized single walled carbon nanotube containing amino acid based hydrogel: a hybrid nanomaterial  |  Subhasish Roy and Arindam Banerjee *. 2012. RSC Adv. 2: 2105-2111.
  12. Nioplexes encapsulated in supramolecular hybrid biohydrogels as versatile delivery platforms for nucleic acids  |  Santiago Grijalvo abc, Gustavo Puras cd, Jon Zárate cd, Ramon Pons b, Jose Luis Pedraz cd, Ramon Eritja bc and David Díaz Díaz *ab. 2016. RSC Adv. 6: 39688-39699.
  13. Photoresponsive Supramolecular Hydrogel Co-assembled from Fmoc-Phe-OH and 4,4′-Azopyridine for Controllable Dye Release  |  Xiao-Qiu Dou, Chang-Li Zhao, Nabila Mehwish, Ping Li, Chuan-Liang Feng & Holger Schönherr. 2019. Chinese Journal of Polymer Science. 37: 437–443.
  14. Supramolecular nanofiber-reinforced Puerarin hydrogels as drug carriers with synergistic controlled release and antibacterial properties  |  Wan Li. 2020. Journal of Materials Science. 55: 6669–6677.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Fmoc-Phe-OH, 5 g

sc-300739
5 g
$20.00

Fmoc-Phe-OH, 25 g

sc-300739A
25 g
$64.00