Fmoc-O1Pen-OH (CAS 260367-12-2)
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Fmoc-O1Pen-OH is a PEG linker that consists of an Fmoc-protected amine and a carboxylic acid group at the terminus. The presence of the hydrophilic PEG spacer enhances its solubility in aqueous solutions. By subjecting the Fmoc group to basic conditions, the amine can be deprotected, yielding a free amine for subsequent conjugation reactions. Additionally, the terminal carboxylic acid can react with primary amine groups in the presence of activators such as EDC or HATU, resulting in the formation of a stable amide bond. This versatile compound has been used in the development of innovative techniques and processes, such as the synthesis of peptides, proteins, organic compounds, complex carbohydrates, and the modification of existing compounds.
Fmoc-O1Pen-OH (CAS 260367-12-2) References
- Rational epitope design for protein targeting. | Peri, C., et al. 2013. ACS Chem Biol. 8: 397-404. PMID: 23138758
- Biophysical Characterization of Nucleophosmin Interactions with Human Immunodeficiency Virus Rev and Herpes Simplex Virus US11. | Nouri, K., et al. 2015. PLoS One. 10: e0143634. PMID: 26624888
- Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR. | Stevers, LM., et al. 2016. Proc Natl Acad Sci U S A. 113: E1152-61. PMID: 26888287
- Structural interface between LRRK2 and 14-3-3 protein. | Stevers, LM., et al. 2017. Biochem J. 474: 1273-1287. PMID: 28202711
- Structure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein-protein interactions. | Sijbesma, E., et al. 2020. Nat Commun. 11: 3954. PMID: 32770072
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fmoc-O1Pen-OH, 1 g | sc-294974 | 1 g | $130.00 | |||
Fmoc-O1Pen-OH, 5 g | sc-294974A | 5 g | $520.00 |