Fmoc-L-Tyr(3-I)-OH (CAS 134486-00-3)

Fmoc-L-Tyr(3-I)-OH, or Fmoc-3-iodo-L-tyrosine, is a synthetic derivative of the amino acid tyrosine, characterized by the incorporation of an iodine atom at the 3-position of the aromatic ring of tyrosine and protected at the amino group by the fluorenylmethyloxycarbonyl (Fmoc) group. This modification significantly alters its physicochemical properties and reactivity compared to the parent molecule. The presence of the iodine atom introduces a unique handle for further chemical modifications, making it particularly useful in the field of peptide synthesis and radio-labeling studies. The Fmoc group, a common protecting group for amino acids in solid-phase peptide synthesis, allows for the selective deprotection under basic conditions without affecting the peptide bond formation process. This compound plays a role in the synthesis of peptides and proteins with specific modifications, enabling researchers to study protein structure-function relationships, protein-protein interactions, and the role of post-translational modifications in various biochemical pathways. Its utility extends to the development of novel peptides and proteins with enhanced properties for use in a wide range of biochemical and biophysical research applications.