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Fmoc-Glu(OtBu)-OH (CAS 71989-18-9)

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Alternate Names:
Fmoc-L-glutamic acid 5-tert-butyl ester
CAS Number:
71989-18-9
Purity:
98%
Molecular Weight:
425.47
Molecular Formula:
C24H27NO6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Fmoc-Glu(OtBu)-OH is a protected amino acid used in solid-phase peptide synthesis (SPPS). The Fmoc group prevents the amino acid from reacting with other molecules, allowing it to be incorporated into a peptide without reacting with other components. The O-tert-butyl ester group also helps to protect the amino acid from unwanted reactions. Fmoc-Glu(OtBu)-OH is employed to create peptides with strong binding affinity and selectivity, as well as to modify existing proteins.


Fmoc-Glu(OtBu)-OH (CAS 71989-18-9) References

  1. Solid-Phase Synthesis of Consolidated Ligands Containing an Intramolecular Lactam Bridge: Comparison of Strategies and Tactics  |  Jaya T. Varkey, David Cowburn, Hong Ji & George Barany. Peptides: The Wave of the Future. 222–223.
  2. Synthesis of bis- and tris-branched COOH-terminal pegylating reagents: conjugation to NH2-terminal peptides  |  A.M. Felix, R.M. Bandaranayake. The Journal of Peptide Research.
  3. Synthesis and structural characterization of sialic acid-glutamic acid hybrid foldamers as conformational surrogates of alpha-2,8-linked polysialic acid.  |  Saludes, JP., et al. 2009. J Am Chem Soc. 131: 5495-505. PMID: 19323529
  4. A paclitaxel-conjugated adenovirus vector for targeted drug delivery for tumor therapy.  |  Shan, L., et al. 2012. Biomaterials. 33: 146-62. PMID: 21959006
  5. Preparation, chromatographic evaluation and comparison between linear peptide- and cyclopeptide-bonded stationary phases.  |  Li, J., et al. 2013. Talanta. 109: 152-9. PMID: 23618153
  6. Solid-phase peptide synthesis (SPPS), C-terminal vs. side-chain anchoring: a reality or a myth.  |  Cherkupally, P., et al. 2014. Amino Acids. 46: 1827-38. PMID: 24770904
  7. Highly sensitive and selective detection of Al(III) ions in aqueous buffered solution with fluorescent peptide-based sensor.  |  In, B., et al. 2016. Bioorg Med Chem Lett. 26: 4477-4482. PMID: 27503680
  8. Total Synthesis of L-156,373 and an oxoPiz Analogue via a Submonomer Approach.  |  Elbatrawi, YM., et al. 2018. Org Lett. 20: 2707-2710. PMID: 29667833
  9. Electron Acceptive Mass Tag for Mass Spectrometric Imaging-Guided Synergistic Targeting to Mice Brain Glutamate Receptors.  |  Jiang, R., et al. 2019. ACS Chem Neurosci. 10: 757-767. PMID: 30576595
  10. Presentation of functional groups on self-assembled supramolecular peptide nanofibers mimicking glycosaminoglycans for directed mesenchymal stem cell differentiation.  |  Yasa, O., et al. 2017. J Mater Chem B. 5: 4890-4900. PMID: 32264005
  11. A Dual-Locked Tandem Fluorescent Probe for Imaging of Pyroptosis in Cancer Chemo-Immunotherapy.  |  Wang, X., et al. 2023. Adv Mater. 35: e2206510. PMID: 36317605
  12. Identification and structural basis of C-terminal cyclic imides as natural degrons for cereblon.  |  Heim, C., et al. 2022. Biochem Biophys Res Commun. 637: 66-72. PMID: 36375252
  13. Discovery of novel OXM-based glucagon-like peptide 1 (GLP-1)/glucagon receptor dual agonists.  |  Zhang, X., et al. 2023. Peptides. 161: 170948. PMID: 36646385
  14. Sequence-assisted peptide synthesis (SAPS).  |  Due Larsen, B. and Holm, A. 1998. J Pept Res. 52: 470-6. PMID: 9924991

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Fmoc-Glu(OtBu)-OH, 10 g

sc-235185
10 g
$109.00