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Fmoc-Cys(Trt)-OH (CAS 103213-32-7)

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Alternate Names:
N-(9-Fluorenylmethoxycarbonyl)-S-trityl-L-cysteine Nα-Fmoc-S-trityl-L-cysteine
Application:
Fmoc-Cys(Trt)-OH is an Fmoc protected cysteine derivative
CAS Number:
103213-32-7
Purity:
≥98%
Molecular Weight:
585.71
Molecular Formula:
C37H31NO4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Fmoc-Cys(Trt)-OH used in peptide synthesis as a protecting group for the thiol group of cysteine. It functions by temporarily blocking the reactivity of the thiol group, allowing for selective deprotection and subsequent modification of the cysteine residue during peptide assembly. Fmoc-Cys(Trt)-OH acts by forming a stable covalent bond with the thiol group, preventing unwanted side reactions and ensuring the integrity of the peptide sequence. Through its mechanism of action, Fmoc-Cys(Trt)-OH enables precise control over the synthesis of cysteine-containing peptides, facilitating the production of complex peptide structures with high purity and yield.


Fmoc-Cys(Trt)-OH (CAS 103213-32-7) References

  1. Parallel Synthesis of Structurally Diverse Aminobenzimidazole Tethered Sultams and Benzothiazepinones.  |  Dadiboyena, S. and Nefzi, A. 2012. Tetrahedron Lett. 53: 6897-6900. PMID: 23209332
  2. The investigation of Fmoc-cysteine derivatives in solid phase peptide synthesis.  |  McCurdy, SN. 1989. Pept Res. 2: 147-52. PMID: 2577698
  3. A paclitaxel prodrug with bifunctional folate and albumin binding moieties for both passive and active targeted cancer therapy.  |  Shan, L., et al. 2018. Theranostics. 8: 2018-2030. PMID: 29556370
  4. Efficient Chemical Protein Synthesis using Fmoc-Masked N-Terminal Cysteine in Peptide Thioester Segments.  |  Kar, A., et al. 2020. Angew Chem Int Ed Engl. 59: 14796-14801. PMID: 32333711
  5. Synthesis of the very acid-sensitive Fmoc-Cys(Mmt)-OH and its application in solid-phase peptide synthesis.  |  Barlos, K., et al. 1996. Int J Pept Protein Res. 47: 148-53. PMID: 8740963

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Fmoc-Cys(Trt)-OH, 5 g

sc-228159
5 g
$48.00