Fmoc-cis-DL-3-phenyl-Pro-OH (CAS 181824-45-3)

Fmoc-cis-DL-3-phenyl-Pro-OH is a compound utilized in peptide synthesis, particularly as a building block for the incorporation of cis-3-phenylproline residues into peptides. Its Fmoc (9-fluorenylmethoxycarbonyl) protective group is strategically important in solid-phase peptide synthesis, allowing for selective deprotection under mild base conditions without affecting the integrity of the peptide chain. Research involving this compound focuses on the synthesis of peptides with constrained conformations, which are of interest for studying protein-protein interactions and the development of peptide-based probes. The cis configuration of the proline residue introduces a kink in the peptide chain, which can be pivotal in the folding and function of the final peptide structure. This characteristic makes Fmoc-cis-DL-3-phenyl-Pro-OH an essential component in the study of structure-activity relationships of peptides, providing insights into the influence of stereochemistry and conformation on biological activity.