Molecular structure of Fmoc chloride, CAS Number: 28920-43-6
Fmoc chloride (CAS 28920-43-6)
Alternate Names:
9-Fluorenylmethoxycarbonyl chloride; 9-Fluorenylmethyl chloroformate; Fmoc-Cl
Application:
Fmoc chloride is used for the precolumn derivatization of amines
CAS Number:
28920-43-6
Purity:
≥98%
Molecular Weight:
258.70
Molecular Formula:
C15H11ClO2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Fmoc chloride is a versatile reagent used for the precolumn derivatization of amines for HPLC and fluorescent detection (abs.: 265 nm, em.: 315 nm). It is also used for capillary electrophoresis. Furthermore, it is employed in synthetic organic chemistry for the protection of carboxylic acids, alcohols, and amines. Specifically, Fmoc chloride forms a stable ester bond with the carboxyl group of an amino acid. This bond is resistant to hydrolysis and other chemical reactions. Fmoc chloride is an important tool for the preparation of peptides, peptidomimetics, and other bioactive molecules.
Fmoc chloride (CAS 28920-43-6) References
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- Photocatalytic Indole Diels-Alder Cycloadditions Mediated by Heterogeneous Platinum-Modified Titanium Dioxide. | Pitre, SP., et al. 2017. ACS Catal. 7: 6440-6444. PMID: 29104813
- Synthesis of Oligosaccharide Components of the Outer Core Domain of P. aeruginosa Lipopolysaccharide Using a Multifunctional Hydroquinone-Derived Reducing-End Capping Group. | Vartak, A., et al. 2018. Org Lett. 20: 353-356. PMID: 29285926
- Determination of l-norvaline and l-tryptophan in dietary supplements by nano-LC using an O-[2-(methacryloyloxy)-ethylcarbamoyl]-10,11-dihydroquinidine-silica hybrid monolithic column. | Xu, D., et al. 2020. J Pharm Anal. 10: 70-77. PMID: 32123601
- Post-Synthesis Modification of Photoluminescent and Electrochemiluminescent Au Nanoclusters with Dopamine. | Kim, JH. and Kim, J. 2020. Nanomaterials (Basel). 11: PMID: 33375457
- Design of Transmembrane Mimetic Structural Probes to Trap Different Stages of γ-Secretase-Substrate Interaction. | Bhattarai, S., et al. 2021. J Med Chem. 64: 15367-15378. PMID: 34647731
- Discovery of Dolastatinol: A Synthetic Analog of Dolastatin 10 and Low Nanomolar Inhibitor of Tubulin Polymerization. | Gutman, H., et al. 2021. ACS Med Chem Lett. 12: 1596-1604. PMID: 34676042
- Identification of a Novel Neuropeptide S Receptor Antagonist Scaffold Based on the SHA-68 Core. | Zarkin, A., et al. 2021. Pharmaceuticals (Basel). 14: PMID: 34681248
- Molecular basis of enzymatic nitrogen-nitrogen formation by a family of zinc-binding cupin enzymes. | Zhao, G., et al. 2021. Nat Commun. 12: 7205. PMID: 34893622
- Quantification of amino groups on halloysite surfaces using the Fmoc-method. | Fidecka, K., et al. 2020. RSC Adv. 10: 13944-13948. PMID: 35498455
- A solid-phase approach for the synthesis of α-aminoboronic acid peptides. | Daniels, BE. and Stivala, CE. 2018. RSC Adv. 8: 3343-3347. PMID: 35541192
- Design and Characterization of In-One Protease-Esterase PluriZyme. | Fernandez-Lopez, L., et al. 2022. Int J Mol Sci. 23: PMID: 36362119
- Azobenzene-Based Amino Acids for the Photocontrol of Coiled-Coil Peptides. | Crone, NSA., et al. 2023. Bioconjug Chem. 34: 345-357. PMID: 36705971
- Azapeptide activity-based probes for the SARS-CoV-2 main protease enable visualization of inhibition in infected cells. | Vanhoutte, R., et al. 2023. Chem Sci. 14: 1666-1672. PMID: 36819852
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fmoc chloride, 1 g | sc-215054 | 1 g | $63.00 | |||
Fmoc chloride, 5 g | sc-215054A | 5 g | $192.00 |