Date published: 2026-4-5

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Fmoc-Arg(Pbf)-OH (CAS 154445-77-9)

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Alternate Names:
Nα-Fmoc-Nω-(2,2,4,6,7-pentamethyldihydro-benzofuran-5-sulfonyl)-L-arginine
CAS Number:
154445-77-9
Purity:
≥98%
Molecular Weight:
648.77
Molecular Formula:
C34H40N4O7S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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The Fmoc-Arg(Pbf)-OH molecule engages with the active site of enzymes, playing a pivotal role in regulating their activity. This interaction is thought to exert a modulatory effect on the enzyme′s function. Additionally, Fmoc-Arg(Pbf)-OH is known to enhance the solubility of peptides and proteins, making them more readily dispersible in aqueous environments. Furthermore, it imparts heightened stability to peptides and proteins, ensuring their structural integrity over extended periods. These properties of Fmoc-Arg(Pbf)-OH contribute to its significance in various biochemical and biotechnological applications, offering valuable insights into the modulation and preservation of peptide and protein molecules.


Fmoc-Arg(Pbf)-OH (CAS 154445-77-9) References

  1. Revisiting NO2 as Protecting Group of Arginine in Solid-Phase Peptide Synthesis.  |  Alhassan, M., et al. 2020. Int J Mol Sci. 21: PMID: 32586051
  2. 2-Cyanoisonicotinamide Conjugation: A Facile Approach to Generate Potent Peptide Inhibitors of the Zika Virus Protease.  |  Patil, NA., et al. 2021. ACS Med Chem Lett. 12: 732-737. PMID: 34055219
  3. Metabolically stable apelin-analogues, incorporating cyclohexylalanine and homoarginine, as potent apelin receptor activators.  |  Fernandez, KX., et al. 2021. RSC Med Chem. 12: 1402-1413. PMID: 34458742
  4. Screening of Self-Assembling of Collagen IV Fragments into Stable Structures Potentially Useful in Regenerative Medicine.  |  Kolasa, M., et al. 2021. Int J Mol Sci. 22: PMID: 34948383
  5. Rapid synthesis of internal peptidyl α-ketoamides by on resin oxidation for the construction of rhomboid protease inhibitors.  |  Van Kersavond, T., et al. 2021. RSC Adv. 11: 4196-4199. PMID: 35424368
  6. Hydroxamic Acid-Modified Peptide Library Provides Insights into the Molecular Basis for the Substrate Selectivity of HDAC Corepressor Complexes.  |  Archibald, LJ., et al. 2022. ACS Chem Biol. 17: 2572-2582. PMID: 35973051
  7. Solid-Phase Synthesis of an 'Inaccessible' hGH-Derived Peptide Using a Pseudoproline Monomer and SIT-Protection for Cysteine.  |  Manne, SR., et al. 2022. ACS Omega. 7: 28487-28492. PMID: 35990446
  8. A diselenobis-functionalized magnetic catalyst based on iron oxide/silica nanoparticles suggested for amidation reactions.  |  Taheri-Ledari, R., et al. 2022. Sci Rep. 12: 14865. PMID: 36050366
  9. Nα -Methylation of arginine: Implications for cell-penetrating peptides.  |  Calabretta, LO., et al. 2023. J Pept Sci. 29: e3468. PMID: 36494904
  10. A hybrid nanoassembly for ultrasound-inducible cytosolic siRNA delivery and cancer sono-gene therapy.  |  Li, G., et al. 2023. Ultrason Sonochem. 92: 106262. PMID: 36512940
  11. An effective antimicrobial complex of nanoscale β-cyclodextrin and ciprofloxacin conjugated to a cell adhesive dipeptide.  |  Taheri-Ledari, R., et al. 2022. RSC Adv. 12: 35383-35395. PMID: 36544467
  12. Synthesis of Polysubstituted Pyridines and Pyrazines via Truce-Smiles Rearrangement of Amino Acid-Based 4-Nitrobenzenesulfonamides.  |  Tkadlecová, M., et al. 2023. J Org Chem. 88: 3228-3237. PMID: 36797215
  13. Influence of Lipidation Pattern of the KR12 Fragment of Peptide LL-37 on Its Antibacterial and Hemolytic Activities.  |  Kamysz, E., et al. 2023. Int J Mol Sci. 24: PMID: 36982579
  14. A Chemical Strategy for the Preparation of Multimodified Peptide Imaging Probes.  |  De Rosa, L., et al. 2023. J Org Chem. 88: 4546-4553. PMID: 36988421

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Fmoc-Arg(Pbf)-OH, 5 g

sc-228152
5 g
$101.00