Fmoc-4,5-dehydro-L-leucine (CAS 87720-55-6)

Fmoc-4,5-dehydro-L-leucine is an amino acid derivative extensively utilized in the field of peptide synthesis, particularly in the realm of creating peptides with altered conformational properties and enhanced biological stability. The Fmoc (9-fluorenylmethoxycarbonyl) group serves as a protective group for the amino functionality, facilitating its incorporation into peptides via standard solid-phase peptide synthesis techniques. The unique structural attribute of this compound, the 4,5-dehydro modification, introduces a degree of rigidity within the peptide backbone. This modification not only influences the secondary structure of the resultant peptide but also plays a pivotal role in probing the structure-activity relationships within biological systems. By altering peptide conformation, researchers can investigate the impact of structure on the interaction between peptides and their respective targets, such as enzymes, receptors, and antibodies. Thus, Fmoc-4,5-dehydro-L-leucine is instrumental in the development of peptides with specific biological activities and enhanced stability, providing useful for the advancement of research in peptide chemistry and molecular biology.