Fmoc-3-(Boc-aminomethyl)phenylalanine (CAS 266999-24-0)

Fmoc-3-(Boc-aminomethyl)phenylalanine is a specialized amino acid derivative extensively utilized in the field of peptide synthesis, particularly in the context of solid-phase peptide synthesis (SPPS). This compound is characterized by the presence of two protective groups: the fluorenylmethyloxycarbonyl (Fmoc) group, which protects the amino terminus, and the tert-butoxycarbonyl (Boc) group, which safeguards the side chain amine functionality. The Fmoc group is strategically designed to be removed under mild basic conditions, allowing for the sequential addition of amino acids without affecting the integrity of the peptide chain. Meanwhile, the Boc group can be cleaved under acidic conditions, offering a distinct, orthogonal deprotection strategy that facilitates the site-specific modification of peptides. This dual protection strategy is critical for the synthesis of complex peptides and proteins, enabling researchers to precisely control the assembly and modification of peptide chains for various research applications, including the study of protein-protein interactions, enzyme-substrate relationships, and the elucidation of biological pathways. The incorporation of Fmoc-3-(Boc-aminomethyl)phenylalanine into peptides paves the way for the introduction of side-chain functionalities and the exploration of structural and functional aspects of peptides and proteins in a research setting.