Fmoc-(3-aminomethyl) benzoic acid (CAS 155369-11-2)

Fmoc-(3-aminomethyl) benzoic acid is a compound utilized in the synthesis of peptides, especially in solid-phase peptide synthesis (SPPS). The Fmoc group, a fluorenylmethyloxycarbonyl protecting group, is employed to temporarily protect the amine functionality of the amino acid during the stepwise construction of peptides. This group is stable to the acidic conditions used for removing most protecting groups but can be selectively removed with a base, which makes it very useful in iterative peptide elongation processes. In addition to its use in synthesizing linear peptides, Fmoc-(3-aminomethyl) benzoic acid is also valuable for incorporating side-chain functionality and branching points in peptide chains, enabling the design of more complex peptide architectures. The compound is fundamental in research focused on developing new synthetic methodologies and in the study of protein-protein interactions, as it allows for the precise assembly of peptides with desired sequences and structures. Researchers also investigate its role in creating peptide-based materials with potential applications in biomaterials science.