Date published: 2026-5-24

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Fmoc-2-Nal-OH (CAS 112883-43-9)

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Alternate Names:
Fmoc-3-(2-naphthyl)-L-alanine
CAS Number:
112883-43-9
Molecular Weight:
437.49
Molecular Formula:
C28H23NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Fmoc-2-Nal-OH is an organic, aromatic compound. Fmoc-2-Nal-OH has been utilized in the synthesis of fluorescent dyes employed in fluorescence microscopy applications. Additionally, it has found application in the preparation of peptide-based inhibitors, specifically targeting protein-protein interactions. Moreover, Fmoc-2-Nal-OH has been employed in the synthesis of various molecules, including peptide and peptidomimetic compounds.


Fmoc-2-Nal-OH (CAS 112883-43-9) References

  1. Preparation of human Melanocortin-4 receptor agonist libraries: linear peptides X-Y-DPhe7-Arg8-Trp(or 2-Nal)9-Z-NH2.  |  Cheung, AW., et al. 2005. Bioorg Med Chem Lett. 15: 5504-8. PMID: 16203134
  2. Identification of potent, selective, and metabolically stable peptide antagonists to the calcitonin gene-related peptide (CGRP) receptor.  |  Miranda, LP., et al. 2008. J Med Chem. 51: 7889-97. PMID: 19053766
  3. A hybrid hydrogel for efficient removal of methyl violet from aqueous solutions.  |  Wang, J., et al. 2010. Colloids Surf B Biointerfaces. 80: 155-60. PMID: 20619619
  4. Peptide antagonists of the calcitonin gene-related peptide (CGRP) receptor with improved pharmacokinetics and pharmacodynamics.  |  Miranda, LP., et al. 2013. Biopolymers. 100: 422-30. PMID: 23868210
  5. The physical properties of supramolecular peptide assemblies: from building block association to technological applications.  |  Adler-Abramovich, L. and Gazit, E. 2014. Chem Soc Rev. 43: 6881-93. PMID: 25099656
  6. Weak Bond-Based Injectable and Stimuli Responsive Hydrogels for Biomedical Applications.  |  Ding, X. and Wang, Y. 2017. J Mater Chem B. 5: 887-906. PMID: 29062484
  7. Effects of Linker Modification on Tumor-to-Kidney Contrast of 68Ga-Labeled PSMA-Targeted Imaging Probes.  |  Kuo, HT., et al. 2018. Mol Pharm. 15: 3502-3511. PMID: 29920108
  8. Enhancing Treatment Efficacy of 177Lu-PSMA-617 with the Conjugation of an Albumin-Binding Motif: Preclinical Dosimetry and Endoradiotherapy Studies.  |  Kuo, HT., et al. 2018. Mol Pharm. 15: 5183-5191. PMID: 30251544
  9. Design, Synthesis, and Characterization of Macrocyclic Inhibitors of the Proprotein Convertase Furin.  |  Van Lam van, T., et al. 2019. ChemMedChem. 14: 673-685. PMID: 30680958
  10. Functionally Versatile and Highly Stable Chelator for 111In and 177Lu: Proof-of-Principle Prostate-Specific Membrane Antigen Targeting.  |  Li, L., et al. 2019. Bioconjug Chem. 30: 1539-1553. PMID: 31009566
  11. Battacin-Inspired Ultrashort Peptides: Nanostructure Analysis and Antimicrobial Activity.  |  Glossop, HD., et al. 2019. Biomacromolecules. 20: 2515-2529. PMID: 31145611
  12. Design, Synthesis, and Evaluation of Linker-Optimised PSMA-Targeting Radioligands.  |  Lundmark, F., et al. 2022. Pharmaceutics. 14: PMID: 35631684
  13. Refined Chelator Spacer Moieties Ameliorate the Pharmacokinetics of PSMA-617.  |  Dos Santos, JC., et al. 2022. Front Chem. 10: 898692. PMID: 36017165
  14. Synthesis and evaluation of a multifunctional probe with a high affinity for prostate-specific membrane antigen (PSMA) and bone.  |  Hirata, S., et al. 2022. Nucl Med Biol. 114-115: 34-41. PMID: 36088875
  15. Synthesis and radiolabelling of PSMA-targeted derivatives containing GYK/MVK cleavable linkers.  |  Murce, E., et al. 2023. R Soc Open Sci. 10: 220950. PMID: 36908985

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Fmoc-2-Nal-OH, 1 g

sc-228148
1 g
$243.00