FMO1 Antibody (H-10): sc-376924
- FMO1 Antibody (H-10) is a mouse monoclonal IgG1 κ FMO1 antibody, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 275-305 within an internal region of FMO1 of human origin
- FMO1 Antibody (H-10) is recommended for detection of FMO1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and equine, bovine and porcine
- Anti-FMO1 Antibody (H-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG1 BP-HRP is the preferred secondary detection reagent for FMO1 Antibody (H-10) for WB and IHC(P) applications. This reagent is now offered in a bundle with FMO1 Antibody (H-10) (see ordering information below).
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FMO1 Antibody (H-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects FMO1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-FMO1 antibody (H-10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. FMO1, also known as dimethylaniline oxidase 1, plays a crucial role in the oxidative metabolism of xenobiotics, such as drugs and pesticides, by catalyzing the N-oxygenation of secondary and tertiary amines. This enzymatic activity is vital for detoxifying harmful compounds and facilitating their excretion from the body, thereby contributing to the maintenance of homeostasis and protection against potential toxic effects. FMO1 is primarily localized to the microsome and endoplasmic reticulum membranes, with expression observed in the liver of human fetuses, which diminishes shortly after birth, while continuing in the adult kidney and, to a lesser extent, in the intestine. In contrast, in other mammals, FMO1 expression persists in the liver postnatally. The gene encoding FMO1 is located on chromosome 1q24.3, and proper function is essential for the metabolic processing of various therapeutic agents, underscoring its importance in pharmacology and toxicology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
FMO1 Antibody (H-10) References:
- Increased incidence of FMO1 gene single nucleotide polymorphisms in sporadic amyotrophic lateral sclerosis. | Cereda, C., et al. 2006. Amyotroph Lateral Scler. 7: 227-34. PMID: 17127561
- Analysis of FMO genes and off flavour in pork. | Glenn, KL., et al. 2007. J Anim Breed Genet. 124: 35-8. PMID: 17302959
- Metabolism and disposition of a selective alpha(7) nicotinic acetylcholine receptor agonist in humans. | Shaffer, CL., et al. 2007. Drug Metab Dispos. 35: 1188-95. PMID: 17446264
- Alternative promoters and repetitive DNA elements define the species-dependent tissue-specific expression of the FMO1 genes of human and mouse. | Shephard, EA., et al. 2007. Biochem J. 406: 491-9. PMID: 17547558
- Deletion of the mouse Fmo1 gene results in enhanced pharmacological behavioural responses to imipramine. | Hernandez, D., et al. 2009. Pharmacogenet Genomics. 19: 289-99. PMID: 19262426
- In vitro metabolism and inhibitory effects of pranlukast in human liver microsomes. | Yoneda, K., et al. 2009. Biol Pharm Bull. 32: 688-93. PMID: 19336906
- Effect of hyperosmotic conditions on flavin-containing monooxygenase activity, protein and mRNA expression in rat kidney. | Rodríguez-Fuentes, G., et al. 2009. Toxicol Lett. 187: 115-8. PMID: 19429252
- Flavin-containing monooxygenase 1-catalysed N,N-dimethylamphetamine N-oxidation. | Lee, SK., et al. 2009. Xenobiotica. 39: 680-6. PMID: 19552509
- Identification of multiple rabbit flavin-containing monooxygenase form 1 (FMO1) gene promoters and observation of tissue-specific DNase I hypersensitive sites. | Luo, Z. and Hines, RN. 1996. Arch Biochem Biophys. 336: 251-60. PMID: 8954572
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FMO1 Antibody (H-10) | sc-376924 | 200 µg/ml | $316.00 | |||
FMO1 Antibody (H-10): m-IgG1 BP-HRP Bundle | sc-531725 | 200 µg Ab; 20 µg BP | $354.00 | |||
FMO1 Antibody (H-10) AC | sc-376924 AC | 500 µg/ml, 25% agarose | $416.00 | |||
FMO1 Antibody (H-10) HRP | sc-376924 HRP | 200 µg/ml | $316.00 | |||
FMO1 Antibody (H-10) FITC | sc-376924 FITC | 200 µg/ml | $330.00 | |||
FMO1 Antibody (H-10) PE | sc-376924 PE | 200 µg/ml | $343.00 | |||
FMO1 Antibody (H-10) Alexa Fluor® 488 | sc-376924 AF488 | 200 µg/ml | $357.00 | |||
FMO1 Antibody (H-10) Alexa Fluor® 546 | sc-376924 AF546 | 200 µg/ml | $357.00 | |||
FMO1 Antibody (H-10) Alexa Fluor® 594 | sc-376924 AF594 | 200 µg/ml | $357.00 | |||
FMO1 Antibody (H-10) Alexa Fluor® 647 | sc-376924 AF647 | 200 µg/ml | $357.00 | |||
FMO1 Antibody (H-10) Alexa Fluor® 680 | sc-376924 AF680 | 200 µg/ml | $357.00 | |||
FMO1 Antibody (H-10) Alexa Fluor® 790 | sc-376924 AF790 | 200 µg/ml | $357.00 | |||
FMO1 (H-10) Neutralizing Peptide | sc-376924 P | 100 µg/0.5 ml | $68.00 |