FMO1 Activators
FMO1 Activators are a collection of chemical compounds that increase the functional activity of Flavin-containing Monooxygenase 1 (FMO1) through their role as substrates for the enzyme's catalytic action. Compounds such as methimazole and trimethylamine are metabolized by FMO1 through N-oxygenation, a process that is integral to the detoxification of these substances and indicative of FMO1's role in processing nitrogen-containing compounds. Similarly, benzydamine, cimetidine, and nicotine are all substrates for FMO1, undergoing N-oxidation that increases the enzyme's activity. This specific interaction between FMO1 and its substrates highlights the enzyme's contribution to the metabolism of drugs and dietary compounds. Furthermore, indole's S-oxygenation by FMO1 underscores the enzyme's versatility in metabolizing heterocyclic compounds.
Continuing with the theme of drug metabolism, FMO1's activity is further enhanced by its interaction with ranitidine, ketoconazole, mephenytoin, tiamulin, omeprazole, and sulindac, which undergo S-oxidation when processed by FMO1. The presence of these compounds necessitates the upregulation of FMO1's oxidative capabilities, thereby increasing its functional activity.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cimetidine | 51481-61-9 | sc-202996 sc-202996A | 5 g 10 g | $62.00 $86.00 | 1 | |
Cimetidine is metabolized by FMO1 through N-oxidation. The drug's presence can stimulate FMO1 activity by increasing the demand for its enzymatic function. | ||||||
Indole | 120-72-9 | sc-257606 sc-257606A sc-257606B sc-257606C sc-257606D | 25 g 100 g 250 g 1 kg 5 kg | $30.00 $69.00 $124.00 $270.00 $1301.00 | 3 | |
As a substrate for FMO1, indole is S-oxygenated, which can lead to an increase in FMO1's functional activity through substrate availability. | ||||||
Ranitidine | 66357-35-5 | sc-203679 | 1 g | $193.00 | ||
Ranitidine undergoes N-oxidation mediated by FMO1. This reaction could lead to the functional enhancement of FMO1 due to increased substrate interaction. | ||||||
Ketoconazole | 65277-42-1 | sc-200496 sc-200496A | 50 mg 500 mg | $63.00 $265.00 | 21 | |
Ketoconazole can be metabolized by FMO1 through N-oxidation, suggesting a role for FMO1 in antifungal drug metabolism and potential upregulation of FMO1 activity. | ||||||
Omeprazole | 73590-58-6 | sc-202265 | 50 mg | $67.00 | 4 | |
Omeprazole is a known FMO1 substrate via S-oxidation. By providing a substrate for FMO1, omeprazole can enhance the functional activity of the enzyme. | ||||||
Sulindac | 38194-50-2 | sc-202823 sc-202823A sc-202823B | 1 g 5 g 10 g | $32.00 $86.00 $150.00 | 3 | |
Sulindac is metabolized by FMO1 through S-oxidation, indicating that its presence could enhance FMO1 activity by acting as a substrate for the enzyme. | ||||||