Molecular structure of FM19G11, CAS Number: 329932-55-0
FM19G11 (CAS 329932-55-0)
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Alternate Names:
HIF-1α/2α Inhibitor IV; HIF Inhibitor IV; 2-Oxo-2-((p-tolyl)ethyl)-3-((2,4-dinitro)benzamido)-benzoate
Application:
FM19G11 is an inhibitor of Hypoxia Inducible Factors α (HIFα)
CAS Number:
329932-55-0
Molecular Weight:
463.40
Molecular Formula:
C23H17N3O8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
FM19G11 is an inhibitor of Hypoxia Inducible Factors α (HIFα), which are transcription factors that respond to changes in available oxygen in the cellular environment. Among other functions (like angiogenesis), HIFα proteins affect the self-renewal and the differentiation processes of stem cells. FM19G11 inhibits the HIFα proteins that repress the target genes of the two α subunits, in various tumor cell lines as well as in adult and embryonic stem cell (ESC) models.
FM19G11 (CAS 329932-55-0) References
- FM19G11, a new hypoxia-inducible factor (HIF) modulator, affects stem cell differentiation status. | Moreno-Manzano, V., et al. 2010. J Biol Chem. 285: 1333-42. PMID: 19897487
- FM19G11: A new modulator of HIF that links mTOR activation with the DNA damage checkpoint pathways. | Rodríguez-Jiménez, FJ., et al. 2010. Cell Cycle. 9: 2803-13. PMID: 20676050
- FM19G11 favors spinal cord injury regeneration and stem cell self-renewal by mitochondrial uncoupling and glucose metabolism induction. | Rodríguez-Jimnez, FJ., et al. 2012. Stem Cells. 30: 2221-33. PMID: 22865656
- Methacrylate-endcapped caprolactone and FM19G11 provide a proper niche for spinal cord-derived neural cells. | Valdes-Sánchez, T., et al. 2015. J Tissue Eng Regen Med. 9: 734-9. PMID: 23533014
- Inhibition of mTOR and HIF pathways diminishes chondro-osteogenesis and cell proliferation in chondroblastoma. | Yang, X., et al. 2013. Tumour Biol. 34: 3111-9. PMID: 23760978
- FM19G11 reverses endothelial dysfunction in rat and human arteries through stimulation of the PI3K/Akt/eNOS pathway, independently of mTOR/HIF-1α activation. | El Assar, M., et al. 2015. Br J Pharmacol. 172: 1277-91. PMID: 25363469
- HIF2α contributes to antiestrogen resistance via positive bilateral crosstalk with EGFR in breast cancer cells. | Alam, MW., et al. 2016. Oncotarget. 7: 11238-50. PMID: 26849233
- Cisplatin treatment increases stemness through upregulation of hypoxia-inducible factors by interleukin-6 in non-small cell lung cancer. | Zhang, F., et al. 2016. Cancer Sci. 107: 746-54. PMID: 27009878
- FM19G11 and Ependymal Progenitor/Stem Cell Combinatory Treatment Enhances Neuronal Preservation and Oligodendrogenesis after Severe Spinal Cord Injury. | Alastrue-Agudo, A., et al. 2018. Int J Mol Sci. 19: PMID: 29315225
- FM19G11 inhibits O6 -methylguanine DNA-methyltransferase expression under both hypoxic and normoxic conditions. | You, CG., et al. 2018. Cancer Med. 7: 3292-3300. PMID: 29761922
- FM19G11-Loaded Gold Nanoparticles Enhance the Proliferation and Self-Renewal of Ependymal Stem Progenitor Cells Derived from ALS Mice. | Marcuzzo, S., et al. 2019. Cells. 8: PMID: 30909571
- Possible Contribution of Inflammation-Associated Hypoxia to Increased K2P5.1 K+ Channel Expression in CD4+ T cells of the Mouse Model for Inflammatory Bowel Disease. | Endo, K., et al. 2019. Int J Mol Sci. 21: PMID: 31861667
- DOT1L regulates MTDH-mediated angiogenesis in triple-negative breast cancer: intermediacy of NF-κB-HIF1α axis. | Neeli, PK., et al. 2023. FEBS J. 290: 502-520. PMID: 36017623
Inhibitor of:
Ferroportin-1, HID, HIF, and TEF-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FM19G11, 10 mg | sc-364490 | 10 mg | $134.00 | |||
FM19G11, 25 mg | sc-364490A | 25 mg | $509.00 |