Molecular structure of Fluvastatin, Sodium Salt, CAS Number: 93957-55-2
Fluvastatin, Sodium Salt (CAS 93957-55-2)
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Alternate Names:
Vastin; Lescol; sodium (3S,5R,E)-7-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl)-3,5-dihydroxyhept-6-enoate
Application:
Fluvastatin, Sodium Salt is an inhibitor of HMGCR (HMG-CoA reductase)
CAS Number:
93957-55-2
Purity:
≥98%
Molecular Weight:
433.45
Molecular Formula:
C24H25FNO4•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Fluvastatin, Sodium Salt is a synthetic inhibitor of HMGCR (HMG-CoA reductase) (IC50 = 40-100 nM for human liver microsomes) that acts as an anti-hypercholesterolemic compound and as an antioxidant. Fluvastatin also inhibits induction of the LDL receptor on HepG2 cells at a concentration of 0.1-1.0 muM. Research shows that fluvastatin can inhibit the formation of TBA-reactive substances in Fe(II)-supported peroxidation of liposomes (IC50 = 12 muM).
Fluvastatin, Sodium Salt (CAS 93957-55-2) References
- HMG-CoA reductase activity in human liver microsomes: comparative inhibition by statins. | Dansette, PM., et al. 2000. Exp Toxicol Pathol. 52: 145-8. PMID: 10965989
- HMG-CoA reductase inhibitors and P-glycoprotein modulation. | Bogman, K., et al. 2001. Br J Pharmacol. 132: 1183-92. PMID: 11250868
- Antioxidative effect of fluvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on peroxidation of phospholipid liposomes. | Yamamoto, A., et al. 2001. J Pharm Pharmacol. 53: 227-32. PMID: 11273020
- Fluvastatin depresses the enhanced lipid peroxidation in vitamin E-deficient hamsters. | Suzumura, K., et al. 2001. Free Radic Res. 35: 815-23. PMID: 11811532
- Pharmacokinetics of fluvastatin after single and multiple doses in normal volunteers. | Tse, FL., et al. 1992. J Clin Pharmacol. 32: 630-8. PMID: 1640002
- Atorvastatin is 10-fold more active in vitro than other statins against Plasmodium falciparum. | Pradines, B., et al. 2007. Antimicrob Agents Chemother. 51: 2654-5. PMID: 17502414
- Effects of fluvastatin (XU 62-320), an HMG-CoA reductase inhibitor, on the distribution and composition of low density lipoprotein subspecies in humans. | Yuan, JN., et al. 1991. Atherosclerosis. 87: 147-57. PMID: 1854361
- In-vitro release kinetics and stability of anticardiovascular drugs-intercalated layered double hydroxide nanohybrids. | Panda, HS., et al. 2009. J Phys Chem B. 113: 15090-100. PMID: 19831399
- Fluvastatin in the first-line therapy of acute coronary syndrome: results of the multicenter, randomized, double-blind, placebo-controlled trial (the FACS-trial). | Ostadal, P., et al. 2010. Trials. 11: 61. PMID: 20500832
- In vitro evaluation of inhibitory effects of antidiabetic and antihyperlipidemic drugs on human carboxylesterase activities. | Fukami, T., et al. 2010. Drug Metab Dispos. 38: 2173-8. PMID: 20810539
- Simvastatin Sodium Salt and Fluvastatin Interact with Human Gap Junction Gamma-3 Protein. | Marsh, A., et al. 2016. PLoS One. 11: e0148266. PMID: 26863535
- Extrapolation of In Vivo Hepatic Clearance from In Vitro Uptake Clearance by Suspended Human Hepatocytes for Anionic Drugs with High Binding to Human Albumin: Improvement of In Vitro-to-In Vivo Extrapolation by Considering the 'Albumin-Mediated' Hepatic Uptake Mechanism on the Basis of the 'Facilitated-Dissociation Model'. | Kim, SJ., et al. 2019. Drug Metab Dispos. 47: 94-103. PMID: 30504137
- Effect of Fluvastatin on Cardiovascular Complications in Kidney Transplant Patients: A Systemic Review and Meta-analysis. | Hwang, SD., et al. 2019. Transplant Proc. 51: 2710-2713. PMID: 31447193
- A High-Content Screen Identifies Drugs That Restrict Tumor Cell Extravasation across the Endothelial Barrier. | Hilfenhaus, G., et al. 2021. Cancer Res. 81: 619-633. PMID: 33218969
- Effect of fluvastatin sodium (XU62-320), a new inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on the induction of low-density lipoprotein receptor in HepG2 cells. | Hayashi, K., et al. 1993. Biochim Biophys Acta. 1167: 223-5. PMID: 8466953
Inhibitor of:
APCDD1L, ATP-binding cassette (ABC) transporter, GPR87, HMGCR, IDI1, LIPH, LSR, MARCH (membrane associated ring-CH-type finger), and ZDHHC7.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fluvastatin, Sodium Salt, 25 mg | sc-202613 | 25 mg | $91.00 | |||
Fluvastatin, Sodium Salt, 50 mg | sc-202613A | 50 mg | $135.00 | |||
Fluvastatin, Sodium Salt, 100 mg | sc-202613B | 100 mg | $241.00 |