Date published: 2026-5-2

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Fluvastatin Lactone (CAS 94061-83-3)

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Application:
Fluvastatin Lactone is a synthetic HMGCR (HMG-CoA reductase) inhibitor
CAS Number:
94061-83-3
Molecular Weight:
393.45
Molecular Formula:
C24H24FNO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Fluvastatin lactone is a compound that inhibits the enzyme HMG-CoA reductase, which plays a key role in the biosynthesis of cholesterol. By inhibiting this enzyme, fluvastatin lactone reduces the production of cholesterol in cells. This compound binds to the active site of HMG-CoA reductase, preventing the enzyme from catalyzing the conversion of HMG-CoA to mevalonate. As a result, the synthesis of cholesterol is decreased, leading to lower levels of cholesterol in the cell. This mechanism of action makes fluvastatin lactone may be useful in studying the regulation of cholesterol biosynthesis and its impact on cellular processes. The inhibition of HMG-CoA reductase by fluvastatin lactone can provide insights into the molecular pathways involved in cholesterol metabolism.


Fluvastatin Lactone (CAS 94061-83-3) References

  1. A comparison of the effects of 3-hydroxy-3-methylglutaryl-coenzyme a (HMG-CoA) reductase inhibitors on the CYP3A4-dependent oxidation of mexazolam in vitro.  |  Ishigami, M., et al. 2001. Drug Metab Dispos. 29: 282-8. PMID: 11181496
  2. Fluvastatin and fluvastatin extended release: a clinical and safety profile.  |  Asberg, A. and Holdaas, H. 2004. Expert Rev Cardiovasc Ther. 2: 641-52. PMID: 15350166
  3. Metabolic properties of the acid and lactone forms of HMG-CoA reductase inhibitors.  |  Fujino, H., et al. 2004. Xenobiotica. 34: 961-71. PMID: 15801541
  4. Statin induced myotoxicity: the lactone forms are more potent than the acid forms in human skeletal muscle cells in vitro.  |  Skottheim, IB., et al. 2008. Eur J Pharm Sci. 33: 317-25. PMID: 18294823
  5. Potentially new isobaric metabolite of fluvastatin observed by LC-MS/MS during incurred sample analysis.  |  Taillon, MP., et al. 2011. Bioanalysis. 3: 1827-35. PMID: 21877892
  6. Translational insight into statin-induced muscle toxicity: from cell culture to clinical studies.  |  Taha, DA., et al. 2014. Transl Res. 164: 85-109. PMID: 24530275
  7. Development of MEPS-UHPLC-MS/MS multistatin methods for clinical analysis.  |  Vlčková, H., et al. 2016. Bioanalysis. 8: 333-49. PMID: 26858167
  8. The Role of Structure and Biophysical Properties in the Pleiotropic Effects of Statins.  |  Murphy, C., et al. 2020. Int J Mol Sci. 21: PMID: 33228116
  9. Effects of acid and lactone forms of statins on S-warfarin 7-hydroxylation catalyzed by human liver microsomes and recombinant CYP2C9 variants (CYP2C9.1 and CYP2C9.3).  |  Shiozawa, A., et al. 2021. Drug Metab Pharmacokinet. 36: 100364. PMID: 33341662
  10. Comparison of properties of four inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.  |  Blum, CB. 1994. Am J Cardiol. 73: 3D-11D. PMID: 8198021

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Fluvastatin Lactone, 5 mg

sc-218520
5 mg
$321.00