Molecular structure of Fluticasone propionate, CAS Number: 80474-14-2
Fluticasone propionate (CAS 80474-14-2)
Alternate Names:
Flixonase
Application:
Fluticasone propionate is a high-affinity, selective glucocorticoid receptor agonist
CAS Number:
80474-14-2
Purity:
≥98%
Molecular Weight:
500.57
Molecular Formula:
C25H31F3O5S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Fluticasone propionate is a high affinity, selective glucocorticoid receptor (GR) agonist (Kd = 0.5 nM). Fluticasone propionate potently stimulates glucocorticoid receptor-mediated transactivation of gene expression and enhances human eosinophil apoptosis (EC50 = 3.7 nM) in vitro. Fluticasone propionate is a lipophilic anti-inflammatory agent derived from flumethasone (sc-211520).
Fluticasone propionate (CAS 80474-14-2) References
- Intranasal fluticasone propionate inhibits allergen induced bone marrow eosinophilia in mice. | Sergejeva, S., et al. 2002. Pulm Pharmacol Ther. 15: 129-34. PMID: 12090786
- Inhaled fluticasone propionate reduces concentration of Mycoplasma pneumoniae, inflammation, and bronchial hyperresponsiveness in lungs of mice. | Chu, HW., et al. 2004. J Infect Dis. 189: 1119-27. PMID: 14999617
- Combined fluticasone propionate and salmeterol reduces RSV infection more effectively than either of them alone in allergen-sensitized mice. | Singam, R., et al. 2006. Virol J. 3: 32. PMID: 16719922
- Repeated instillations of Dermatophagoides farinae into the airways can induce Th2-dependent airway hyperresponsiveness, eosinophilia and remodeling in mice: effect of intratracheal treatment of fluticasone propionate. | Wakahara, K., et al. 2008. Eur J Pharmacol. 578: 87-96. PMID: 17915213
- Fluticasone propionate reduces bacterial airway epithelial invasion. | Barbier, M., et al. 2008. Eur Respir J. 32: 1283-8. PMID: 18684852
- Wet-wrap treatment using dilutions of tacrolimus ointment and fluticasone propionate cream in human APOC1 (+/+) mice with atopic dermatitis. | Oranje, AP., et al. 2009. Br J Dermatol. 160: 54-61. PMID: 18795918
- A pilot study of fluticasone propionate in untreated coeliac disease. | Mitchison, HC., et al. 1991. Gut. 32: 260-5. PMID: 1901562
- A dose-ranging study of fluticasone propionate aqueous nasal spray for seasonal allergic rhinitis assessed by symptoms, rhinomanometry, and nasal cytology. | Meltzer, EO., et al. 1990. J Allergy Clin Immunol. 86: 221-30. PMID: 2200821
- Inhaled fluticasone propionate impairs pulmonary clearance of Klebsiella pneumoniae in mice. | Patterson, CM., et al. 2012. Respir Res. 13: 40. PMID: 22651370
- Effect of fluticasone propionate on virus-induced airways inflammation and anti-viral immune responses in mice. | Singanayagam, A., et al. 2015. Lancet. 385 Suppl 1: S88. PMID: 26312910
- Fetal Concentrations of Budesonide and Fluticasone Propionate: a Study in Mice. | Zaidi, S., et al. 2019. AAPS J. 21: 53. PMID: 30993489
- Nanoparticle drug delivery characterization for fluticasone propionate and in vitro testing 1. | Sutariya, V., et al. 2019. Can J Physiol Pharmacol. 97: 675-684. PMID: 31100204
- Beneficial Immunomodulatory Effects of Fluticasone Propionate in Chlamydia pneumoniae-Infected Mice. | Paróczai, D., et al. 2021. Pathogens. 10: PMID: 33799333
- Treatment with Fluticasone Propionate Increases Antibiotic Efficacy during Treatment of Late-Stage Primary Pneumonic Plague. | Crane, SD., et al. 2022. Antimicrob Agents Chemother. 66: e0127521. PMID: 34780267
- Synthesis and structure-activity relationships in a series of antiinflammatory corticosteroid analogues, halomethyl androstane-17 beta-carbothioates and -17 beta-carboselenoates. | Phillipps, GH., et al. 1994. J Med Chem. 37: 3717-29. PMID: 7966132
Inhibitor of:
C1orf49, cryptdin 21, IL-17, Olfr305, Olfr371, Olfr792, Olfr794, Olfr798, and Tenascin-X.Activator of:
AGP-1, GR, KDELC2, and SP-D.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fluticasone propionate, 10 mg | sc-218517 | 10 mg | $180.00 |